Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth

Ovarian cancer is the leading cause of fatality among gynecological malignancies. Ovarian cancer growth is angiogenesis-dependent, and an increased production of angiogenic growth factors such as vascular endothelial growth factor is prognostically significant even during early stages of the disease...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-04, Vol.60 (8), p.2190
Hauptverfasser:	Yokoyama, Y, Dhanabal, M, Griffioen, A W, Sukhatme, V P, Ramakrishnan, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiostatins Animals Apoptosis - drug effects Cell Division - drug effects Chick Embryo Chorion - blood supply Chorion - drug effects Collagen - genetics Collagen - isolation & purification Collagen - pharmacology Collagen - therapeutic use Drug Synergism Endostatins Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Female Humans Inhibitory Concentration 50 Mice Mice, Nude Neoplasm Transplantation Neoplasm, Residual - blood supply Neoplasm, Residual - pathology Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Ovarian Neoplasms - blood supply Ovarian Neoplasms - drug therapy Ovarian Neoplasms - pathology Peptide Fragments - genetics Peptide Fragments - isolation & purification Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Pichia - genetics Plasminogen - genetics Plasminogen - isolation & purification Plasminogen - pharmacology Plasminogen - therapeutic use Recombinant Proteins - isolation & purification Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Tumor Cells, Cultured
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