Synthesis and pharmacology of new enantiopure delta(3)-4-arylkainoids

Seven delta(3)-4-arylkainoids possessing various 4-position aromatic and heteroaromatic groups were synthesized and their apparent affinities were measured in order to explore the influences of 4-position electron density and stereochemistry on receptor affinity and specificity. Kainoids 1a-f were s...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-04, Vol.10 (8), p.771
Hauptverfasser:	Rondeau, D, Gill, P, Chan, M, Curry, K, Lubell, W D
Format:	Artikel
Sprache:	eng
Schlagworte:	Excitatory Amino Acid Agonists - chemical synthesis Excitatory Amino Acid Agonists - pharmacology Kainic Acid - chemical synthesis Kainic Acid - pharmacology Receptors, N-Methyl-D-Aspartate - agonists Stereoisomerism
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