Nuclear Structure in Normal and Bloom Syndrome Cells

Bloom syndrome (BS) is a rare cancer-predisposing disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability. BLM, the protein altered in BS, is a RecQ DNA helicase. This report shows that BLM is found in the nucleus of normal human cells in the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-05, Vol.97 (10), p.5214-5219
Hauptverfasser:	Yankiwski, Victor, Marciniak, Robert A., Guarente, Leonard, Neff, Norma F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - analysis Adolescent Adult Antibodies Biological Sciences Bloom Syndrome - enzymology Bloom Syndrome - genetics Bloom Syndrome - pathology Cancer Cell cycle Cell Line Cell lines Cell nucleolus Cell Nucleolus - enzymology Cell Nucleolus - ultrastructure Cell nucleus Cell Nucleus - enzymology Cell Nucleus - pathology Cell Nucleus - ultrastructure Cellular biology Child Child, Preschool Consanguinity Deoxyribonucleic acid Diploidy DNA DNA Helicases - analysis Exodeoxyribonucleases Female Fibroblasts Humans Interphase Jews - genetics Male Medical disorders Middle Aged Pedigree Polymorphism, Restriction Fragment Length RecQ Helicases RecQ protein Reference Values S Phase Telomere - enzymology Telomere - ultrastructure Telomeres Werner Syndrome - enzymology Werner Syndrome Helicase
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