The involvement of singlet oxygen in copper-phenanthroline/H2O2-induced DNA base damage: a chemiluminescent study

Copper in the presence of excess 1,10-phenanthroline, a reducing agent, and H 2 O 2 causes DNA base damage as well as strand breakage. We have reported in previous work that a strong chemiluminescence was followed by DNA base damage in this system, which is characteristic of guanine. In the present...

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Veröffentlicht in:	Redox report : communications in free radical research 1999-01, Vol.4 (6), p.271-276
Hauptverfasser:	Ma, W-J., Cao, E-H., Qin, J-F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid - pharmacology DNA Damage Free Radical Scavengers - pharmacology Hydrogen Peroxide - toxicity Hydroxyl Radical Luminescent Measurements Oxygen - pharmacology Phenanthrolines - toxicity
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