p38 mitogen-activated protein kinase regulates a novel, caspase-independent pathway for the mitochondrial cytochrome c release in ultraviolet B radiation-induced apoptosis

The mechanisms of UVB-induced apoptosis and the role of p38 mitogen-activated protein kinase (MAPK) were investigated in HaCaT cells. UVB doses that induced apoptosis also produced a sustained activation of p38 MAPK and mitochondrial cytochrome c release, leading to pro-caspase-3 activation. Late in...

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Veröffentlicht in:	The Journal of biological chemistry 2000-07, Vol.275 (28), p.21416
Hauptverfasser:	Assefa, Z, Vantieghem, A, Garmyn, M, Declercq, W, Vandenabeele, P, Vandenheede, J R, Bouillon, R, Merlevede, W, Agostinis, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Chloromethyl Ketones - pharmacology Apoptosis - physiology Apoptosis - radiation effects Caspase Inhibitors Cell Division - drug effects Cell Division - radiation effects Cell Line Cysteine Proteinase Inhibitors - pharmacology Cytochrome c Group - metabolism Humans Imidazoles - pharmacology Keratinocytes - cytology Keratinocytes - physiology Keratinocytes - radiation effects Kinetics Mitogen-Activated Protein Kinases - metabolism Mitogen-Activated Protein Kinases - radiation effects p38 Mitogen-Activated Protein Kinases Ultraviolet Rays
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