Fulminant hepatic failure : Etiology, viral markers and outcome
To investigate the etiology and outcome of fulminant hepatic failure (FHF) in children. Hospital based descriptive. 36 children (22 males and 14 females) presenting with FHF over a period of one year were investigated. The ages ranged from 1.5 to 9 years. FHF was defined as occurrence of encephalopa...
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| Veröffentlicht in: | Indian pediatrics 1999-11, Vol.36 (11), p.1107-1112 |
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| creator | BENDRE, S. V BAVDEKAR, A. R BHAVE, S. A PANDIT, A. N CHITAMBAR, S. D ARANKALLE, V. A |
| description | To investigate the etiology and outcome of fulminant hepatic failure (FHF) in children.
Hospital based descriptive.
36 children (22 males and 14 females) presenting with FHF over a period of one year were investigated. The ages ranged from 1.5 to 9 years. FHF was defined as occurrence of encephalopathy within eight weeks of onset of jaundice with no evidence of pre-existing liver disease. Detailed history, clinical examination, routine biochemical parameters and relevant diagnostic tests were carried out. Viral markers studied were anti HAV-IgM, HBsAg, anti HBc-IgM, anti-HCV and anti HEV-IgM.
A viral etiology could be established in 22 children (61.1%). Hepatitis A (n = 12), Hepatitis B (n = 3), Hepatitis A and B (n = 2), and Hepatitis A and E (n = 4). Two children had enteric fever (1 with associated HEV), 2 children had Wilson's disease, 1 child had Indian Childhood Cirrhosis (ICC) and 2 children had drug induced hepatitis. Etiological diagnosis was not possible in 8 children (22%). Fourteen children (39%) died. Poor outcome was associated with spontaneous bleeding, raised prothrombin time, lower transaminases and higher bilirubin on admission.
Viral hepatitis is the commonest cause of FHF in children. HAV alone or in combination is responsible for upto 50% of all FHF in children. Chronic liver disease can also present as FHF. Etiological diagnosis is not possible to upto one-fourth of all cases. |
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Hospital based descriptive.
36 children (22 males and 14 females) presenting with FHF over a period of one year were investigated. The ages ranged from 1.5 to 9 years. FHF was defined as occurrence of encephalopathy within eight weeks of onset of jaundice with no evidence of pre-existing liver disease. Detailed history, clinical examination, routine biochemical parameters and relevant diagnostic tests were carried out. Viral markers studied were anti HAV-IgM, HBsAg, anti HBc-IgM, anti-HCV and anti HEV-IgM.
A viral etiology could be established in 22 children (61.1%). Hepatitis A (n = 12), Hepatitis B (n = 3), Hepatitis A and B (n = 2), and Hepatitis A and E (n = 4). Two children had enteric fever (1 with associated HEV), 2 children had Wilson's disease, 1 child had Indian Childhood Cirrhosis (ICC) and 2 children had drug induced hepatitis. Etiological diagnosis was not possible in 8 children (22%). Fourteen children (39%) died. Poor outcome was associated with spontaneous bleeding, raised prothrombin time, lower transaminases and higher bilirubin on admission.
Viral hepatitis is the commonest cause of FHF in children. HAV alone or in combination is responsible for upto 50% of all FHF in children. Chronic liver disease can also present as FHF. Etiological diagnosis is not possible to upto one-fourth of all cases.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>PMID: 10745331</identifier><identifier>CODEN: INPDAR</identifier><language>eng</language><publisher>New Delhi: Indian Pediatrics</publisher><subject>Biological and medical sciences ; Chemical and Drug Induced Liver Injury, Chronic - complications ; Chemical and Drug Induced Liver Injury, Chronic - diagnosis ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatic Encephalopathy - etiology ; Hepatic Encephalopathy - mortality ; Hepatic Encephalopathy - virology ; Hepatitis A Virus, Human - immunology ; Hepatitis B Core Antigens - blood ; Hepatitis B Surface Antigens - blood ; Hepatitis C Antibodies - immunology ; Hepatitis Delta Virus - immunology ; Hepatitis E virus - immunology ; Hepatitis, Viral, Human - complications ; Hepatitis, Viral, Human - diagnosis ; Hepatitis, Viral, Human - immunology ; Hepatolenticular Degeneration - complications ; Hepatolenticular Degeneration - diagnosis ; Humans ; India ; Infant ; Jaundice - etiology ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Other diseases. Semiology ; Prognosis ; Survival Analysis ; Tropical medicine ; Typhoid Fever - complications ; Typhoid Fever - diagnosis</subject><ispartof>Indian pediatrics, 1999-11, Vol.36 (11), p.1107-1112</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1314234$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10745331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BENDRE, S. V</creatorcontrib><creatorcontrib>BAVDEKAR, A. R</creatorcontrib><creatorcontrib>BHAVE, S. A</creatorcontrib><creatorcontrib>PANDIT, A. N</creatorcontrib><creatorcontrib>CHITAMBAR, S. D</creatorcontrib><creatorcontrib>ARANKALLE, V. A</creatorcontrib><title>Fulminant hepatic failure : Etiology, viral markers and outcome</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><description>To investigate the etiology and outcome of fulminant hepatic failure (FHF) in children.
Hospital based descriptive.
36 children (22 males and 14 females) presenting with FHF over a period of one year were investigated. The ages ranged from 1.5 to 9 years. FHF was defined as occurrence of encephalopathy within eight weeks of onset of jaundice with no evidence of pre-existing liver disease. Detailed history, clinical examination, routine biochemical parameters and relevant diagnostic tests were carried out. Viral markers studied were anti HAV-IgM, HBsAg, anti HBc-IgM, anti-HCV and anti HEV-IgM.
A viral etiology could be established in 22 children (61.1%). Hepatitis A (n = 12), Hepatitis B (n = 3), Hepatitis A and B (n = 2), and Hepatitis A and E (n = 4). Two children had enteric fever (1 with associated HEV), 2 children had Wilson's disease, 1 child had Indian Childhood Cirrhosis (ICC) and 2 children had drug induced hepatitis. Etiological diagnosis was not possible in 8 children (22%). Fourteen children (39%) died. Poor outcome was associated with spontaneous bleeding, raised prothrombin time, lower transaminases and higher bilirubin on admission.
Viral hepatitis is the commonest cause of FHF in children. HAV alone or in combination is responsible for upto 50% of all FHF in children. Chronic liver disease can also present as FHF. Etiological diagnosis is not possible to upto one-fourth of all cases.</description><subject>Biological and medical sciences</subject><subject>Chemical and Drug Induced Liver Injury, Chronic - complications</subject><subject>Chemical and Drug Induced Liver Injury, Chronic - diagnosis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatic Encephalopathy - etiology</subject><subject>Hepatic Encephalopathy - mortality</subject><subject>Hepatic Encephalopathy - virology</subject><subject>Hepatitis A Virus, Human - immunology</subject><subject>Hepatitis B Core Antigens - blood</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis C Antibodies - immunology</subject><subject>Hepatitis Delta Virus - immunology</subject><subject>Hepatitis E virus - immunology</subject><subject>Hepatitis, Viral, Human - complications</subject><subject>Hepatitis, Viral, Human - diagnosis</subject><subject>Hepatitis, Viral, Human - immunology</subject><subject>Hepatolenticular Degeneration - complications</subject><subject>Hepatolenticular Degeneration - diagnosis</subject><subject>Humans</subject><subject>India</subject><subject>Infant</subject><subject>Jaundice - etiology</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>Tropical medicine</subject><subject>Typhoid Fever - complications</subject><subject>Typhoid Fever - diagnosis</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj01LAzEYhIMotlb_guTg0YV8bjZeREqrQsGLnsubbKLR7AdJVui_d8GKpxmYh2HmBC2JVqJSUurT2ROqq5rUdIEucv4khHEm6TlaUKKE5Jwu0f12il3ooS_4w41QgsUeQpySw3d4U8IQh_fDLf4OCSLuIH25lDH0LR6mYofOXaIzDzG7q6Ou0Nt287p-qnYvj8_rh101UklLZbQnxNS2sZ6BtqSZB2ijrGHEGJDguCdCUNEwcNKbOWwsFbbligJvleYrdP3bO06mc-1-TGFec9j_PZmBmyMA2UL0CXob8j_HqWBc8B9VClIb</recordid><startdate>199911</startdate><enddate>199911</enddate><creator>BENDRE, S. V</creator><creator>BAVDEKAR, A. R</creator><creator>BHAVE, S. A</creator><creator>PANDIT, A. N</creator><creator>CHITAMBAR, S. D</creator><creator>ARANKALLE, V. A</creator><general>Indian Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199911</creationdate><title>Fulminant hepatic failure : Etiology, viral markers and outcome</title><author>BENDRE, S. V ; BAVDEKAR, A. R ; BHAVE, S. A ; PANDIT, A. N ; CHITAMBAR, S. D ; ARANKALLE, V. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p151t-b9f00b6c8cf2a9c080749b7cb20bba5ae3f0441482ae5fb7498c14cd371a3d793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Chemical and Drug Induced Liver Injury, Chronic - complications</topic><topic>Chemical and Drug Induced Liver Injury, Chronic - diagnosis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatic Encephalopathy - etiology</topic><topic>Hepatic Encephalopathy - mortality</topic><topic>Hepatic Encephalopathy - virology</topic><topic>Hepatitis A Virus, Human - immunology</topic><topic>Hepatitis B Core Antigens - blood</topic><topic>Hepatitis B Surface Antigens - blood</topic><topic>Hepatitis C Antibodies - immunology</topic><topic>Hepatitis Delta Virus - immunology</topic><topic>Hepatitis E virus - immunology</topic><topic>Hepatitis, Viral, Human - complications</topic><topic>Hepatitis, Viral, Human - diagnosis</topic><topic>Hepatitis, Viral, Human - immunology</topic><topic>Hepatolenticular Degeneration - complications</topic><topic>Hepatolenticular Degeneration - diagnosis</topic><topic>Humans</topic><topic>India</topic><topic>Infant</topic><topic>Jaundice - etiology</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>Tropical medicine</topic><topic>Typhoid Fever - complications</topic><topic>Typhoid Fever - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BENDRE, S. V</creatorcontrib><creatorcontrib>BAVDEKAR, A. R</creatorcontrib><creatorcontrib>BHAVE, S. A</creatorcontrib><creatorcontrib>PANDIT, A. N</creatorcontrib><creatorcontrib>CHITAMBAR, S. D</creatorcontrib><creatorcontrib>ARANKALLE, V. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BENDRE, S. V</au><au>BAVDEKAR, A. R</au><au>BHAVE, S. A</au><au>PANDIT, A. N</au><au>CHITAMBAR, S. D</au><au>ARANKALLE, V. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fulminant hepatic failure : Etiology, viral markers and outcome</atitle><jtitle>Indian pediatrics</jtitle><addtitle>Indian Pediatr</addtitle><date>1999-11</date><risdate>1999</risdate><volume>36</volume><issue>11</issue><spage>1107</spage><epage>1112</epage><pages>1107-1112</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><coden>INPDAR</coden><abstract>To investigate the etiology and outcome of fulminant hepatic failure (FHF) in children.
Hospital based descriptive.
36 children (22 males and 14 females) presenting with FHF over a period of one year were investigated. The ages ranged from 1.5 to 9 years. FHF was defined as occurrence of encephalopathy within eight weeks of onset of jaundice with no evidence of pre-existing liver disease. Detailed history, clinical examination, routine biochemical parameters and relevant diagnostic tests were carried out. Viral markers studied were anti HAV-IgM, HBsAg, anti HBc-IgM, anti-HCV and anti HEV-IgM.
A viral etiology could be established in 22 children (61.1%). Hepatitis A (n = 12), Hepatitis B (n = 3), Hepatitis A and B (n = 2), and Hepatitis A and E (n = 4). Two children had enteric fever (1 with associated HEV), 2 children had Wilson's disease, 1 child had Indian Childhood Cirrhosis (ICC) and 2 children had drug induced hepatitis. Etiological diagnosis was not possible in 8 children (22%). Fourteen children (39%) died. Poor outcome was associated with spontaneous bleeding, raised prothrombin time, lower transaminases and higher bilirubin on admission.
Viral hepatitis is the commonest cause of FHF in children. HAV alone or in combination is responsible for upto 50% of all FHF in children. Chronic liver disease can also present as FHF. Etiological diagnosis is not possible to upto one-fourth of all cases.</abstract><cop>New Delhi</cop><pub>Indian Pediatrics</pub><pmid>10745331</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Indian pediatrics, 1999-11, Vol.36 (11), p.1107-1112 |
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| subjects | Biological and medical sciences Chemical and Drug Induced Liver Injury, Chronic - complications Chemical and Drug Induced Liver Injury, Chronic - diagnosis Child Child, Preschool Diagnosis, Differential Female Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Hepatic Encephalopathy - etiology Hepatic Encephalopathy - mortality Hepatic Encephalopathy - virology Hepatitis A Virus, Human - immunology Hepatitis B Core Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis C Antibodies - immunology Hepatitis Delta Virus - immunology Hepatitis E virus - immunology Hepatitis, Viral, Human - complications Hepatitis, Viral, Human - diagnosis Hepatitis, Viral, Human - immunology Hepatolenticular Degeneration - complications Hepatolenticular Degeneration - diagnosis Humans India Infant Jaundice - etiology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Other diseases. Semiology Prognosis Survival Analysis Tropical medicine Typhoid Fever - complications Typhoid Fever - diagnosis |
| title | Fulminant hepatic failure : Etiology, viral markers and outcome |
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