Irritant thresholds in subjects with colophony allergy
The factors which determine individual susceptibility to the development of allergic contact dermatitis (ACD) are not well defined. Since it is known that the presence of skin irritation is well-documented as a promoter of sensitization, the sensitivity to irritation of subjects with ACD has been co...
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| Veröffentlicht in: | Contact dermatitis 2000-02, Vol.42 (2), p.95-97 |
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| container_title | Contact dermatitis |
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| creator | SMITH, H. R HOLLOWAY, D ARMSTRONG, D. K. B BASKETTER, D. A MCFADDEN, J. P |
| description | The factors which determine individual susceptibility to the development of allergic contact dermatitis (ACD) are not well defined. Since it is known that the presence of skin irritation is well-documented as a promoter of sensitization, the sensitivity to irritation of subjects with ACD has been compared with a normal control group. Whilst 78% of those with a positive patch test reaction to the contact allergen colophony (colophonium) responded to a concentration of no higher than 2.5% sodium lauryl sulfate (SLS), only 44% of the matched control group reacted at this level of SLS. Thus, the results are consistent with the hypothesis that individuals with enhanced susceptibility to skin irritation are also more liable to develop allergic skin reactivity. |
| doi_str_mv | 10.1034/j.1600-0536.2000.042002095.x |
| format | Article |
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Thus, the results are consistent with the hypothesis that individuals with enhanced susceptibility to skin irritation are also more liable to develop allergic skin reactivity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Allergens - adverse effects</subject><subject>Allergic diseases</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dermatitis, Allergic Contact - etiology</subject><subject>Dermatitis, Allergic Contact - physiopathology</subject><subject>Disease Susceptibility</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunopathology</subject><subject>Irritants - administration & dosage</subject><subject>Irritants - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patch Tests</subject><subject>Resins, Plant - adverse effects</subject><subject>Skin - drug effects</subject><subject>Skin allergic diseases. 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Toxic occupational diseases</topic><topic>Dermatitis, Allergic Contact - etiology</topic><topic>Dermatitis, Allergic Contact - physiopathology</topic><topic>Disease Susceptibility</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunopathology</topic><topic>Irritants - administration & dosage</topic><topic>Irritants - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patch Tests</topic><topic>Resins, Plant - adverse effects</topic><topic>Skin - drug effects</topic><topic>Skin allergic diseases. 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P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Irritant thresholds in subjects with colophony allergy</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>42</volume><issue>2</issue><spage>95</spage><epage>97</epage><pages>95-97</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><coden>CODEDG</coden><abstract>The factors which determine individual susceptibility to the development of allergic contact dermatitis (ACD) are not well defined. Since it is known that the presence of skin irritation is well-documented as a promoter of sensitization, the sensitivity to irritation of subjects with ACD has been compared with a normal control group. Whilst 78% of those with a positive patch test reaction to the contact allergen colophony (colophonium) responded to a concentration of no higher than 2.5% sodium lauryl sulfate (SLS), only 44% of the matched control group reacted at this level of SLS. Thus, the results are consistent with the hypothesis that individuals with enhanced susceptibility to skin irritation are also more liable to develop allergic skin reactivity.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>10703632</pmid><doi>10.1034/j.1600-0536.2000.042002095.x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Contact dermatitis, 2000-02, Vol.42 (2), p.95-97 |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adolescent Adult Allergens - adverse effects Allergic diseases Biological and medical sciences Case-Control Studies Chemical and industrial products toxicology. Toxic occupational diseases Dermatitis, Allergic Contact - etiology Dermatitis, Allergic Contact - physiopathology Disease Susceptibility Dose-Response Relationship, Drug Female Humans Immunization Immunopathology Irritants - administration & dosage Irritants - adverse effects Male Medical sciences Middle Aged Patch Tests Resins, Plant - adverse effects Skin - drug effects Skin allergic diseases. Stinging insect allergies Sodium Dodecyl Sulfate - administration & dosage Sodium Dodecyl Sulfate - adverse effects Surface-Active Agents - administration & dosage Surface-Active Agents - adverse effects Tars - adverse effects Toxicology Various organic compounds |
| title | Irritant thresholds in subjects with colophony allergy |
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