Sensitivity to DNA cross‐linking chemotherapeutic agents in mismatch repair‐defective cells in vitro and in xenografts

Together with tolerance to killing induced by methylating agents, loss of mismatch repair (MMR) has previously been found to be associated with hypersensitivity to the DNAcross‐linking agent 1‐(2‐chloroethyl)‐3‐cyclohexyl‐nitrosourea(CCNU) in several human tumor cell lines (Aquilina et al., 1998). H...

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Veröffentlicht in:	International journal of cancer 2000-02, Vol.85 (4), p.590-596
Hauptverfasser:	Fiumicino, Silvia, Martinelli, Simone, Colussi, Claudia, Aquilina, Gabriele, Leonetti, Carlo, Crescenzi, Marco, Bignami, Margherita
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Animals Antineoplastic agents Base Pair Mismatch Biological and medical sciences Burkitt Lymphoma - drug therapy Burkitt Lymphoma - pathology Cell Division - drug effects Chemotherapy Cross-Linking Reagents - therapeutic use Cross-Linking Reagents - toxicity DNA Repair Enzymes DNA-Binding Proteins HeLa Cells Humans Lomustine - therapeutic use Lomustine - toxicity Medical sciences Melphalan - therapeutic use Melphalan - toxicity Mice Mice, Knockout Mice, Nude Micronucleus Tests Mismatch Repair Endonuclease PMS2 Mitomycin - therapeutic use Mitomycin - toxicity MutS Homolog 2 Protein Pharmacology. Drug treatments Proteins - genetics Proto-Oncogene Proteins - deficiency Proto-Oncogene Proteins - genetics Transplantation, Heterologous Tumor Cells, Cultured
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