Risk of Female Breast Cancer Associated with Serum Polychlorinated Biphenyls and 1,1-Dichloro-2,2′-bis(p-chlorophenyl)ethylene
This case-control study was designed to investigate the relationship between polychlorinated biphenyls (PCBs) and 1,1-dichloro-2,2′-bis( p -chlorophenyl)ethylene (DDE) and breast cancer risk in Connecticut. Cases were incident breast cancer patients who were either residents of Tolland County or who...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-02, Vol.9 (2), p.167-174 |
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| creator | TONGZHANG ZHENG HOLFORD, T. R DAWOOD, O ZAHM, S. H MAYNE, S. T TESSARI, J WARD, B CARTER, D OWENS, P. H BOYLE, P DUBROW, R ARCHIBEQUE-ENGLE, S |
| description | This case-control study was designed to investigate the relationship
between polychlorinated biphenyls (PCBs) and
1,1-dichloro-2,2′-bis( p -chlorophenyl)ethylene (DDE) and
breast cancer risk in Connecticut. Cases were incident breast cancer
patients who were either residents of Tolland County or who had a
breast-related surgery at the Yale-New Haven Hospital in New Haven
County. Controls were randomly selected from Tolland County residents
or from patients who had newly diagnosed benign breast diseases or
normal tissue at Yale-New Haven Hospital. A total of 475 cases and 502
controls had their serum samples analyzed for PCBs and DDE in
1995–1997. The age- and lipid-adjusted geometric mean serum level of
DDE was comparable between the cases (460.1 ppb) and controls (456.2
ppb). The geometric mean serum level of PCBs was also comparable
between cases (733.1 ppb) and controls (747.6 ppb). After adjustment
for confounding factors, odds ratios of 0.96 (95% confidence interval,
0.67–1.36) for DDE and 0.95 (95% confidence interval, 0.68–1.32) for
PCBs were observed when the third tertile was compared with the lowest.
Further stratification by parity, lactation, and menopausal and
estrogen receptor status also showed no significant association with
serum levels of DDE or PCBs. The results by PCB congener groups also
showed no major increased risk associated with any of the congener
groups. Our study does not support the hypothesis that DDE and PCBs, as
encountered through environmental exposure, increase the risk of female
breast cancer. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_10698477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10698477</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-ebe5e3d394bdf7bdd758fb4d3756d4ee0ddc09f9512dc20f818406b0e608ee243</originalsourceid><addsrcrecordid>eNpF0N1KwzAUB_AiipvTV5BciCgskKZN01xu06kwUPy4LmlyaqL9GEnH6N2eyUfySZzrxKtzOP8f5-J_EAxDFqWYc8YOtzthDAuRsEFw4v0HIYQLxo6DQUgSkcacD4PNs_WfqCnQHCpZApo6kL5FM1krcGjifaOsbEGjtW0NegG3qtBTU3bKlI2z9S6a2qWBuis9krVG4TjEN3aXN5iO6ffmC-fWXy1xf-vtNbSmK6GG0-CokKWHs_0cBW_z29fZPV483j3MJgtsaCJaDDkwiHQk4lwXPNeas7TIYx1xlugYgGitiCgEC6lWlBRpmMYkyQkkJAWgcTQKzvu_y1Vegc6WzlbSddlfFVtwsQfSK1kWbluB9f-OpoLSX3bZM2Pfzdo6yNSuKwcepFMmExnNwoRHP4lHeHM</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Risk of Female Breast Cancer Associated with Serum Polychlorinated Biphenyls and 1,1-Dichloro-2,2′-bis(p-chlorophenyl)ethylene</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>TONGZHANG ZHENG ; HOLFORD, T. R ; DAWOOD, O ; ZAHM, S. H ; MAYNE, S. T ; TESSARI, J ; WARD, B ; CARTER, D ; OWENS, P. H ; BOYLE, P ; DUBROW, R ; ARCHIBEQUE-ENGLE, S</creator><creatorcontrib>TONGZHANG ZHENG ; HOLFORD, T. R ; DAWOOD, O ; ZAHM, S. H ; MAYNE, S. T ; TESSARI, J ; WARD, B ; CARTER, D ; OWENS, P. H ; BOYLE, P ; DUBROW, R ; ARCHIBEQUE-ENGLE, S</creatorcontrib><description>This case-control study was designed to investigate the relationship
between polychlorinated biphenyls (PCBs) and
1,1-dichloro-2,2′-bis( p -chlorophenyl)ethylene (DDE) and
breast cancer risk in Connecticut. Cases were incident breast cancer
patients who were either residents of Tolland County or who had a
breast-related surgery at the Yale-New Haven Hospital in New Haven
County. Controls were randomly selected from Tolland County residents
or from patients who had newly diagnosed benign breast diseases or
normal tissue at Yale-New Haven Hospital. A total of 475 cases and 502
controls had their serum samples analyzed for PCBs and DDE in
1995–1997. The age- and lipid-adjusted geometric mean serum level of
DDE was comparable between the cases (460.1 ppb) and controls (456.2
ppb). The geometric mean serum level of PCBs was also comparable
between cases (733.1 ppb) and controls (747.6 ppb). After adjustment
for confounding factors, odds ratios of 0.96 (95% confidence interval,
0.67–1.36) for DDE and 0.95 (95% confidence interval, 0.68–1.32) for
PCBs were observed when the third tertile was compared with the lowest.
Further stratification by parity, lactation, and menopausal and
estrogen receptor status also showed no significant association with
serum levels of DDE or PCBs. The results by PCB congener groups also
showed no major increased risk associated with any of the congener
groups. Our study does not support the hypothesis that DDE and PCBs, as
encountered through environmental exposure, increase the risk of female
breast cancer.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 10698477</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Case-Control Studies ; Dichlorodiphenyl Dichloroethylene - adverse effects ; Dichlorodiphenyl Dichloroethylene - blood ; Environmental Exposure ; Environmental Pollutants - adverse effects ; Environmental Pollutants - blood ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Insecticides - adverse effects ; Insecticides - blood ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Polychlorinated Biphenyls - adverse effects ; Polychlorinated Biphenyls - blood ; Receptors, Estrogen - analysis ; Risk Factors ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2000-02, Vol.9 (2), p.167-174</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1289227$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10698477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TONGZHANG ZHENG</creatorcontrib><creatorcontrib>HOLFORD, T. R</creatorcontrib><creatorcontrib>DAWOOD, O</creatorcontrib><creatorcontrib>ZAHM, S. H</creatorcontrib><creatorcontrib>MAYNE, S. T</creatorcontrib><creatorcontrib>TESSARI, J</creatorcontrib><creatorcontrib>WARD, B</creatorcontrib><creatorcontrib>CARTER, D</creatorcontrib><creatorcontrib>OWENS, P. H</creatorcontrib><creatorcontrib>BOYLE, P</creatorcontrib><creatorcontrib>DUBROW, R</creatorcontrib><creatorcontrib>ARCHIBEQUE-ENGLE, S</creatorcontrib><title>Risk of Female Breast Cancer Associated with Serum Polychlorinated Biphenyls and 1,1-Dichloro-2,2′-bis(p-chlorophenyl)ethylene</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>This case-control study was designed to investigate the relationship
between polychlorinated biphenyls (PCBs) and
1,1-dichloro-2,2′-bis( p -chlorophenyl)ethylene (DDE) and
breast cancer risk in Connecticut. Cases were incident breast cancer
patients who were either residents of Tolland County or who had a
breast-related surgery at the Yale-New Haven Hospital in New Haven
County. Controls were randomly selected from Tolland County residents
or from patients who had newly diagnosed benign breast diseases or
normal tissue at Yale-New Haven Hospital. A total of 475 cases and 502
controls had their serum samples analyzed for PCBs and DDE in
1995–1997. The age- and lipid-adjusted geometric mean serum level of
DDE was comparable between the cases (460.1 ppb) and controls (456.2
ppb). The geometric mean serum level of PCBs was also comparable
between cases (733.1 ppb) and controls (747.6 ppb). After adjustment
for confounding factors, odds ratios of 0.96 (95% confidence interval,
0.67–1.36) for DDE and 0.95 (95% confidence interval, 0.68–1.32) for
PCBs were observed when the third tertile was compared with the lowest.
Further stratification by parity, lactation, and menopausal and
estrogen receptor status also showed no significant association with
serum levels of DDE or PCBs. The results by PCB congener groups also
showed no major increased risk associated with any of the congener
groups. Our study does not support the hypothesis that DDE and PCBs, as
encountered through environmental exposure, increase the risk of female
breast cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Case-Control Studies</subject><subject>Dichlorodiphenyl Dichloroethylene - adverse effects</subject><subject>Dichlorodiphenyl Dichloroethylene - blood</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - adverse effects</subject><subject>Environmental Pollutants - blood</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insecticides - adverse effects</subject><subject>Insecticides - blood</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polychlorinated Biphenyls - adverse effects</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Receptors, Estrogen - analysis</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0N1KwzAUB_AiipvTV5BciCgskKZN01xu06kwUPy4LmlyaqL9GEnH6N2eyUfySZzrxKtzOP8f5-J_EAxDFqWYc8YOtzthDAuRsEFw4v0HIYQLxo6DQUgSkcacD4PNs_WfqCnQHCpZApo6kL5FM1krcGjifaOsbEGjtW0NegG3qtBTU3bKlI2z9S6a2qWBuis9krVG4TjEN3aXN5iO6ffmC-fWXy1xf-vtNbSmK6GG0-CokKWHs_0cBW_z29fZPV483j3MJgtsaCJaDDkwiHQk4lwXPNeas7TIYx1xlugYgGitiCgEC6lWlBRpmMYkyQkkJAWgcTQKzvu_y1Vegc6WzlbSddlfFVtwsQfSK1kWbluB9f-OpoLSX3bZM2Pfzdo6yNSuKwcepFMmExnNwoRHP4lHeHM</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>TONGZHANG ZHENG</creator><creator>HOLFORD, T. R</creator><creator>DAWOOD, O</creator><creator>ZAHM, S. H</creator><creator>MAYNE, S. T</creator><creator>TESSARI, J</creator><creator>WARD, B</creator><creator>CARTER, D</creator><creator>OWENS, P. H</creator><creator>BOYLE, P</creator><creator>DUBROW, R</creator><creator>ARCHIBEQUE-ENGLE, S</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20000201</creationdate><title>Risk of Female Breast Cancer Associated with Serum Polychlorinated Biphenyls and 1,1-Dichloro-2,2′-bis(p-chlorophenyl)ethylene</title><author>TONGZHANG ZHENG ; HOLFORD, T. R ; DAWOOD, O ; ZAHM, S. H ; MAYNE, S. T ; TESSARI, J ; WARD, B ; CARTER, D ; OWENS, P. H ; BOYLE, P ; DUBROW, R ; ARCHIBEQUE-ENGLE, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-ebe5e3d394bdf7bdd758fb4d3756d4ee0ddc09f9512dc20f818406b0e608ee243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Case-Control Studies</topic><topic>Dichlorodiphenyl Dichloroethylene - adverse effects</topic><topic>Dichlorodiphenyl Dichloroethylene - blood</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - adverse effects</topic><topic>Environmental Pollutants - blood</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Insecticides - adverse effects</topic><topic>Insecticides - blood</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polychlorinated Biphenyls - adverse effects</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Receptors, Estrogen - analysis</topic><topic>Risk Factors</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TONGZHANG ZHENG</creatorcontrib><creatorcontrib>HOLFORD, T. R</creatorcontrib><creatorcontrib>DAWOOD, O</creatorcontrib><creatorcontrib>ZAHM, S. H</creatorcontrib><creatorcontrib>MAYNE, S. T</creatorcontrib><creatorcontrib>TESSARI, J</creatorcontrib><creatorcontrib>WARD, B</creatorcontrib><creatorcontrib>CARTER, D</creatorcontrib><creatorcontrib>OWENS, P. H</creatorcontrib><creatorcontrib>BOYLE, P</creatorcontrib><creatorcontrib>DUBROW, R</creatorcontrib><creatorcontrib>ARCHIBEQUE-ENGLE, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TONGZHANG ZHENG</au><au>HOLFORD, T. R</au><au>DAWOOD, O</au><au>ZAHM, S. H</au><au>MAYNE, S. T</au><au>TESSARI, J</au><au>WARD, B</au><au>CARTER, D</au><au>OWENS, P. H</au><au>BOYLE, P</au><au>DUBROW, R</au><au>ARCHIBEQUE-ENGLE, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of Female Breast Cancer Associated with Serum Polychlorinated Biphenyls and 1,1-Dichloro-2,2′-bis(p-chlorophenyl)ethylene</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>9</volume><issue>2</issue><spage>167</spage><epage>174</epage><pages>167-174</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>This case-control study was designed to investigate the relationship
between polychlorinated biphenyls (PCBs) and
1,1-dichloro-2,2′-bis( p -chlorophenyl)ethylene (DDE) and
breast cancer risk in Connecticut. Cases were incident breast cancer
patients who were either residents of Tolland County or who had a
breast-related surgery at the Yale-New Haven Hospital in New Haven
County. Controls were randomly selected from Tolland County residents
or from patients who had newly diagnosed benign breast diseases or
normal tissue at Yale-New Haven Hospital. A total of 475 cases and 502
controls had their serum samples analyzed for PCBs and DDE in
1995–1997. The age- and lipid-adjusted geometric mean serum level of
DDE was comparable between the cases (460.1 ppb) and controls (456.2
ppb). The geometric mean serum level of PCBs was also comparable
between cases (733.1 ppb) and controls (747.6 ppb). After adjustment
for confounding factors, odds ratios of 0.96 (95% confidence interval,
0.67–1.36) for DDE and 0.95 (95% confidence interval, 0.68–1.32) for
PCBs were observed when the third tertile was compared with the lowest.
Further stratification by parity, lactation, and menopausal and
estrogen receptor status also showed no significant association with
serum levels of DDE or PCBs. The results by PCB congener groups also
showed no major increased risk associated with any of the congener
groups. Our study does not support the hypothesis that DDE and PCBs, as
encountered through environmental exposure, increase the risk of female
breast cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>10698477</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 2000-02, Vol.9 (2), p.167-174 |
| issn | 1055-9965 1538-7755 |
| language | eng |
| recordid | cdi_pubmed_primary_10698477 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Breast Neoplasms - epidemiology Breast Neoplasms - etiology Case-Control Studies Dichlorodiphenyl Dichloroethylene - adverse effects Dichlorodiphenyl Dichloroethylene - blood Environmental Exposure Environmental Pollutants - adverse effects Environmental Pollutants - blood Female Gynecology. Andrology. Obstetrics Humans Insecticides - adverse effects Insecticides - blood Mammary gland diseases Medical sciences Middle Aged Polychlorinated Biphenyls - adverse effects Polychlorinated Biphenyls - blood Receptors, Estrogen - analysis Risk Factors Tumors |
| title | Risk of Female Breast Cancer Associated with Serum Polychlorinated Biphenyls and 1,1-Dichloro-2,2′-bis(p-chlorophenyl)ethylene |
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