Characterization of an Ovarian Carcinoma Cell Line Resistant to Cisplatin and Flavopiridol

Flavopiridol, the first inhibitor of cyclin-dependent kinases to enter clinical trials, has shown promising antineoplastic activity and is currently undergoing Phase II testing. Little is known about mechanisms of resistance to this agent. In the present study, we have characterized an ovarian carci...

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Veröffentlicht in:	Clinical cancer research 2000-02, Vol.6 (2), p.661-670
Hauptverfasser:	Keith C. Bible, Scott A. Boerner, Kathryn Kirkland, Kari L. Anderl, Duane Bartelt, Jr, Phyllis A. Svingen, Timothy J. Kottke, Yean K. Lee, Steven Eckdahl, Paul G. Stalboerger, Robert B. Jenkins, Scott H. Kaufmann
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - toxicity Biological and medical sciences Carmustine - toxicity Chromosome Aberrations Chromosome Mapping Cisplatin - pharmacokinetics Cisplatin - toxicity DNA Adducts - analysis Drug Resistance, Multiple Drug Resistance, Neoplasm Female Flavonoids - toxicity General aspects Humans Karyotyping Medical sciences Organoplatinum Compounds - pharmacokinetics Organoplatinum Compounds - toxicity Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Pharmacology. Drug treatments Piperidines - toxicity Tumor Cells, Cultured
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