Engineered Herpes Simplex Virus Expressing IL-12 in the Treatment of Experimental Murine Brain Tumors

Genetically engineered, neuroattenuated herpes simplex viruses (HSVs) expressing various cytokines can improve survival when used in the treatment of experimental brain tumors. These attenuated viruses have both copies of γ134.5 deleted. Recently, we demonstrated increased survival of C57BL/6 mice b...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-02, Vol.97 (5), p.2208-2213
Hauptverfasser:	Parker, Jacqueline N., Gillespie, G. Yancey, Love, Cammy E., Randall, Suzanne, Whitley, Richard J., Markert, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Biological Therapy Brain Brain Neoplasms - immunology Brain Neoplasms - therapy CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell lines Chlorocebus aethiops Disease Models, Animal Female Gene Expression Genetic Engineering Genetic Vectors - genetics Glioma Glioma - immunology Glioma - therapy Herpes simplex virus 1 Herpes viruses Herpesvirus 1, Human - genetics Herpesvirus 1, Human - pathogenicity Human herpesvirus 1 Humans Interleukin-12 - genetics Interleukin-12 - immunology Medical research Mice Mice, Inbred A Neuroblastoma - immunology Neuroblastoma - therapy Neurons Recombination, Genetic T lymphocytes Tumor cell line Tumor Cells, Cultured Tumors Vero Cells Virulence Viruses
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