Genetic predisposition to breast cancer: a surgical perspective

Background: Molecular alterations in proto‐oncogenes, tumour suppressor genes, and genes that function in DNA damage recognition and repair are considered to be hallmarks of a carcinogenic process, including breast carcinogenesis. Methods: A computer‐assisted search of the English literature (Medlin...

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Veröffentlicht in:	British journal of surgery 2000-02, Vol.87 (2), p.149-162
Hauptverfasser:	Sakorafas, G. H., Tsiotou, A. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences BRCA2 Protein Breast Neoplasms - genetics Breast Neoplasms - prevention & control Breast Neoplasms - surgery Female Genes, BRCA1 - genetics Genetic Predisposition to Disease - genetics Gynecology. Andrology. Obstetrics Heterozygote Humans Mammary gland diseases Medical sciences Mutation - genetics Neoplasm Proteins - genetics Phosphoric Monoester Hydrolases - genetics PTEN Phosphohydrolase Risk Assessment Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the genital tract and mammary gland Transcription Factors - genetics Tumor Suppressor Proteins Tumors
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