Breast Adipose Tissue Concentrations of Polychlorinated Biphenyls and Other Organochlorines and Breast Cancer Risk
Numerous studies have examined the relationship between organochlorines and breast cancer, but the results are not consistent. In most studies, organochlorines were measured in serum, but levels in breast adipose tissue are higher and represent cumulative internal exposure at the target site for bre...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2000-01, Vol.9 (1), p.55-63 |
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| creator | ARONSON, K. J MILLER, A. B HANNA, W. M SENGUPTA, S. K WEBER, J.-P WOOLCOTT, C. G STERNS, E. E MCCREADY, D. R LICKLEY, L. A FISH, E. B HIRAKI, G. Y HOLLOWAY, C ROSS, T |
| description | Numerous studies have examined the relationship between organochlorines
and breast cancer, but the results are not consistent. In most studies,
organochlorines were measured in serum, but levels in breast adipose
tissue are higher and represent cumulative internal exposure at the
target site for breast cancer. Therefore, a hospital-based case-control
study was conducted in Ontario, Canada to evaluate the association
between breast cancer risk and breast adipose tissue concentrations of
several organochlorines. Women scheduled for excision biopsy of the
breast were enrolled and completed a questionnaire. The biopsy tissue
of 217 cases and 213 benign controls frequency matched by study site
and age in 5-year groups was analyzed for 14 polychlorinated biphenyl
(PCB) congeners, total PCBs, and 10 other organochlorines, including
p,p′-1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene.
Multiple logistic regression was used to assess the magnitude of risk.
While adjusting for age, menopausal status, and other factors, odds
ratios (ORs) were above 1.0 for almost all organochlorines except five
pesticide residues. The ORs were above two in the highest concentration
categories of PCB congeners 105 and 118, and the ORs for these PCBs
increased linearly across categories ( P s for trend≤
0.01). Differences by menopausal status are noted especially for PCBs
105 and 118, with risks higher among premenopausal women, and for PCBs
170 and 180, with risks higher among postmenopausal women. Clear
associations with breast cancer risk were demonstrated in this study
for some PCBs measured in breast adipose tissue. |
| format | Article |
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and breast cancer, but the results are not consistent. In most studies,
organochlorines were measured in serum, but levels in breast adipose
tissue are higher and represent cumulative internal exposure at the
target site for breast cancer. Therefore, a hospital-based case-control
study was conducted in Ontario, Canada to evaluate the association
between breast cancer risk and breast adipose tissue concentrations of
several organochlorines. Women scheduled for excision biopsy of the
breast were enrolled and completed a questionnaire. The biopsy tissue
of 217 cases and 213 benign controls frequency matched by study site
and age in 5-year groups was analyzed for 14 polychlorinated biphenyl
(PCB) congeners, total PCBs, and 10 other organochlorines, including
p,p′-1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene.
Multiple logistic regression was used to assess the magnitude of risk.
While adjusting for age, menopausal status, and other factors, odds
ratios (ORs) were above 1.0 for almost all organochlorines except five
pesticide residues. The ORs were above two in the highest concentration
categories of PCB congeners 105 and 118, and the ORs for these PCBs
increased linearly across categories ( P s for trend≤
0.01). Differences by menopausal status are noted especially for PCBs
105 and 118, with risks higher among premenopausal women, and for PCBs
170 and 180, with risks higher among postmenopausal women. Clear
associations with breast cancer risk were demonstrated in this study
for some PCBs measured in breast adipose tissue.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 10667464</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adipose Tissue - chemistry ; Age Factors ; Biological and medical sciences ; Biopsy ; Breast - chemistry ; Breast Neoplasms - etiology ; Case-Control Studies ; Dichlorodiphenyl Dichloroethylene - analysis ; Environmental Exposure ; Environmental Pollutants - analysis ; Environmental Pollutants - blood ; Environmental Pollutants - classification ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Insecticides - analysis ; Insecticides - blood ; Insecticides - classification ; Logistic Models ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Odds Ratio ; Ontario ; Pesticide Residues - analysis ; Polychlorinated Biphenyls - analysis ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - classification ; Postmenopause ; Premenopause ; Risk Factors ; Surveys and Questionnaires ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2000-01, Vol.9 (1), p.55-63</ispartof><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1283964$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10667464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ARONSON, K. J</creatorcontrib><creatorcontrib>MILLER, A. B</creatorcontrib><creatorcontrib>HANNA, W. M</creatorcontrib><creatorcontrib>SENGUPTA, S. K</creatorcontrib><creatorcontrib>WEBER, J.-P</creatorcontrib><creatorcontrib>WOOLCOTT, C. G</creatorcontrib><creatorcontrib>STERNS, E. E</creatorcontrib><creatorcontrib>MCCREADY, D. R</creatorcontrib><creatorcontrib>LICKLEY, L. A</creatorcontrib><creatorcontrib>FISH, E. B</creatorcontrib><creatorcontrib>HIRAKI, G. Y</creatorcontrib><creatorcontrib>HOLLOWAY, C</creatorcontrib><creatorcontrib>ROSS, T</creatorcontrib><title>Breast Adipose Tissue Concentrations of Polychlorinated Biphenyls and Other Organochlorines and Breast Cancer Risk</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Numerous studies have examined the relationship between organochlorines
and breast cancer, but the results are not consistent. In most studies,
organochlorines were measured in serum, but levels in breast adipose
tissue are higher and represent cumulative internal exposure at the
target site for breast cancer. Therefore, a hospital-based case-control
study was conducted in Ontario, Canada to evaluate the association
between breast cancer risk and breast adipose tissue concentrations of
several organochlorines. Women scheduled for excision biopsy of the
breast were enrolled and completed a questionnaire. The biopsy tissue
of 217 cases and 213 benign controls frequency matched by study site
and age in 5-year groups was analyzed for 14 polychlorinated biphenyl
(PCB) congeners, total PCBs, and 10 other organochlorines, including
p,p′-1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene.
Multiple logistic regression was used to assess the magnitude of risk.
While adjusting for age, menopausal status, and other factors, odds
ratios (ORs) were above 1.0 for almost all organochlorines except five
pesticide residues. The ORs were above two in the highest concentration
categories of PCB congeners 105 and 118, and the ORs for these PCBs
increased linearly across categories ( P s for trend≤
0.01). Differences by menopausal status are noted especially for PCBs
105 and 118, with risks higher among premenopausal women, and for PCBs
170 and 180, with risks higher among postmenopausal women. Clear
associations with breast cancer risk were demonstrated in this study
for some PCBs measured in breast adipose tissue.</description><subject>Adipose Tissue - chemistry</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breast - chemistry</subject><subject>Breast Neoplasms - etiology</subject><subject>Case-Control Studies</subject><subject>Dichlorodiphenyl Dichloroethylene - analysis</subject><subject>Environmental Exposure</subject><subject>Environmental Pollutants - analysis</subject><subject>Environmental Pollutants - blood</subject><subject>Environmental Pollutants - classification</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Insecticides - analysis</subject><subject>Insecticides - blood</subject><subject>Insecticides - classification</subject><subject>Logistic Models</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Ontario</subject><subject>Pesticide Residues - analysis</subject><subject>Polychlorinated Biphenyls - analysis</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - classification</subject><subject>Postmenopause</subject><subject>Premenopause</subject><subject>Risk Factors</subject><subject>Surveys and Questionnaires</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01Lw0AQBuAgiq3VvyB70GNgvzc5tsEvKESknsN2d7ZZTZOwmyL994Y24mkG5uFl3otkTgTLUqWEuBx3LESa51LMkpsYvzDGKhfiOpkRLKXiks-TsAqg44CW1vddBLTxMR4AFV1roB2CHnzXRtQ59N41R1M3XfCtHsCile9raI9NRLq1qBxqCKgMO912k4LzZcov9BgY0IeP37fJldNNhLtpLpLP56dN8Zquy5e3YrlOayrlkFK6BaklUGsYVltOKCOZk5Jxy5ThYJVjJCcsy7hTjhKLneOZMqCl5UJRtkjuz7n9YbsHW_XB73U4Vn_lR_AwAR2NblwYf_Tx39GM5Sf2eGa139U_PkBlTmUCRNDB1FVekUoI9gvP4XJq</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>ARONSON, K. J</creator><creator>MILLER, A. B</creator><creator>HANNA, W. M</creator><creator>SENGUPTA, S. K</creator><creator>WEBER, J.-P</creator><creator>WOOLCOTT, C. G</creator><creator>STERNS, E. E</creator><creator>MCCREADY, D. R</creator><creator>LICKLEY, L. A</creator><creator>FISH, E. B</creator><creator>HIRAKI, G. Y</creator><creator>HOLLOWAY, C</creator><creator>ROSS, T</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>20000101</creationdate><title>Breast Adipose Tissue Concentrations of Polychlorinated Biphenyls and Other Organochlorines and Breast Cancer Risk</title><author>ARONSON, K. J ; MILLER, A. B ; HANNA, W. M ; SENGUPTA, S. K ; WEBER, J.-P ; WOOLCOTT, C. G ; STERNS, E. E ; MCCREADY, D. R ; LICKLEY, L. A ; FISH, E. B ; HIRAKI, G. Y ; HOLLOWAY, C ; ROSS, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-22be6a6e2dc307b412318f6634d37c4ed7f31913884f7f21d0ff487cea6d45723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adipose Tissue - chemistry</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breast - chemistry</topic><topic>Breast Neoplasms - etiology</topic><topic>Case-Control Studies</topic><topic>Dichlorodiphenyl Dichloroethylene - analysis</topic><topic>Environmental Exposure</topic><topic>Environmental Pollutants - analysis</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - classification</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Insecticides - analysis</topic><topic>Insecticides - blood</topic><topic>Insecticides - classification</topic><topic>Logistic Models</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Ontario</topic><topic>Pesticide Residues - analysis</topic><topic>Polychlorinated Biphenyls - analysis</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Polychlorinated Biphenyls - classification</topic><topic>Postmenopause</topic><topic>Premenopause</topic><topic>Risk Factors</topic><topic>Surveys and Questionnaires</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ARONSON, K. J</creatorcontrib><creatorcontrib>MILLER, A. B</creatorcontrib><creatorcontrib>HANNA, W. M</creatorcontrib><creatorcontrib>SENGUPTA, S. K</creatorcontrib><creatorcontrib>WEBER, J.-P</creatorcontrib><creatorcontrib>WOOLCOTT, C. G</creatorcontrib><creatorcontrib>STERNS, E. E</creatorcontrib><creatorcontrib>MCCREADY, D. R</creatorcontrib><creatorcontrib>LICKLEY, L. A</creatorcontrib><creatorcontrib>FISH, E. B</creatorcontrib><creatorcontrib>HIRAKI, G. Y</creatorcontrib><creatorcontrib>HOLLOWAY, C</creatorcontrib><creatorcontrib>ROSS, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ARONSON, K. J</au><au>MILLER, A. B</au><au>HANNA, W. M</au><au>SENGUPTA, S. K</au><au>WEBER, J.-P</au><au>WOOLCOTT, C. G</au><au>STERNS, E. E</au><au>MCCREADY, D. R</au><au>LICKLEY, L. A</au><au>FISH, E. B</au><au>HIRAKI, G. Y</au><au>HOLLOWAY, C</au><au>ROSS, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breast Adipose Tissue Concentrations of Polychlorinated Biphenyls and Other Organochlorines and Breast Cancer Risk</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>9</volume><issue>1</issue><spage>55</spage><epage>63</epage><pages>55-63</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Numerous studies have examined the relationship between organochlorines
and breast cancer, but the results are not consistent. In most studies,
organochlorines were measured in serum, but levels in breast adipose
tissue are higher and represent cumulative internal exposure at the
target site for breast cancer. Therefore, a hospital-based case-control
study was conducted in Ontario, Canada to evaluate the association
between breast cancer risk and breast adipose tissue concentrations of
several organochlorines. Women scheduled for excision biopsy of the
breast were enrolled and completed a questionnaire. The biopsy tissue
of 217 cases and 213 benign controls frequency matched by study site
and age in 5-year groups was analyzed for 14 polychlorinated biphenyl
(PCB) congeners, total PCBs, and 10 other organochlorines, including
p,p′-1,1-dichloro-2,2-bis( p -chlorophenyl)ethylene.
Multiple logistic regression was used to assess the magnitude of risk.
While adjusting for age, menopausal status, and other factors, odds
ratios (ORs) were above 1.0 for almost all organochlorines except five
pesticide residues. The ORs were above two in the highest concentration
categories of PCB congeners 105 and 118, and the ORs for these PCBs
increased linearly across categories ( P s for trend≤
0.01). Differences by menopausal status are noted especially for PCBs
105 and 118, with risks higher among premenopausal women, and for PCBs
170 and 180, with risks higher among postmenopausal women. Clear
associations with breast cancer risk were demonstrated in this study
for some PCBs measured in breast adipose tissue.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>10667464</pmid><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 2000-01, Vol.9 (1), p.55-63 |
| issn | 1055-9965 1538-7755 |
| language | eng |
| recordid | cdi_pubmed_primary_10667464 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Adipose Tissue - chemistry Age Factors Biological and medical sciences Biopsy Breast - chemistry Breast Neoplasms - etiology Case-Control Studies Dichlorodiphenyl Dichloroethylene - analysis Environmental Exposure Environmental Pollutants - analysis Environmental Pollutants - blood Environmental Pollutants - classification Female Gynecology. Andrology. Obstetrics Humans Insecticides - analysis Insecticides - blood Insecticides - classification Logistic Models Mammary gland diseases Medical sciences Middle Aged Odds Ratio Ontario Pesticide Residues - analysis Polychlorinated Biphenyls - analysis Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - classification Postmenopause Premenopause Risk Factors Surveys and Questionnaires Tumors |
| title | Breast Adipose Tissue Concentrations of Polychlorinated Biphenyls and Other Organochlorines and Breast Cancer Risk |
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