Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans
1 University of Adelaide Department of Medicine, Royal Adelaide Hospital, Adelaide 5000, Australia; and 2 Department of Internal Medicine, College of Medicine, Konkuk University, Seoul 143-130, Korea Oral fructose empties from the stomach more rapidly and may suppress food intake more than oral gl...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-02, Vol.278 (2), p.360-R366 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
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| creator | Rayner, C. K Park, H. S Wishart, J. M Kong, M.-F Doran, S. M Horowitz, M |
| description | 1 University of Adelaide Department of
Medicine, Royal Adelaide Hospital, Adelaide 5000, Australia; and
2 Department of Internal Medicine, College of
Medicine, Konkuk University, Seoul 143-130, Korea
Oral fructose empties from the stomach more rapidly and
may suppress food intake more than oral glucose. The purpose of the study was to evaluate the effects of intraduodenal infusions of fructose and glucose on antropyloric motility and appetite. Ten healthy
volunteers were given intraduodenal infusions of 25% fructose, 25%
glucose, or 0.9% saline (2 ml/min for 90 min). Antropyloric pressures,
blood glucose, and plasma insulin, gastric inhibitory peptide (GIP),
and glucagon-like peptide-1 (GLP-1) were measured concurrently; a
buffet meal was offered at the end of the infusion. Intraduodenal
fructose and glucose suppressed antral waves ( P |
| doi_str_mv | 10.1152/ajpregu.2000.278.2.r360 |
| format | Article |
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Medicine, Royal Adelaide Hospital, Adelaide 5000, Australia; and
2 Department of Internal Medicine, College of
Medicine, Konkuk University, Seoul 143-130, Korea
Oral fructose empties from the stomach more rapidly and
may suppress food intake more than oral glucose. The purpose of the study was to evaluate the effects of intraduodenal infusions of fructose and glucose on antropyloric motility and appetite. Ten healthy
volunteers were given intraduodenal infusions of 25% fructose, 25%
glucose, or 0.9% saline (2 ml/min for 90 min). Antropyloric pressures,
blood glucose, and plasma insulin, gastric inhibitory peptide (GIP),
and glucagon-like peptide-1 (GLP-1) were measured concurrently; a
buffet meal was offered at the end of the infusion. Intraduodenal
fructose and glucose suppressed antral waves ( P < 0.0005 for
both), stimulated isolated pyloric pressure waves ( P < 0.05 for both), and increased basal pyloric pressure ( P = 0.10 and
P < 0.05, respectively) compared with saline, without any
significant difference between them. Intraduodenal glucose increased
blood glucose ( P < 0.0005), as well as plasma insulin ( P < 0.0005) and GIP ( P < 0.005) more
than intraduodenal fructose, whereas there was no difference in the
GLP-1 response. Intraduodenal fructose suppressed food intake compared
with saline ( P < 0.05) and glucose ( P = 0.07). We
conclude that, when infused intraduodenally at 2 kcal/min for 90 min
1 ) fructose and glucose have comparable effects on antropyloric
pressures, 2 ) fructose tends to suppress food intake more than
glucose, despite similar GLP-1 and less GIP release, and 3 )
GIP, rather than GLP-1, probably accounts for the greater insulin
response to glucose than fructose.
monosaccharides; manometry; incretins; glucagon-like peptide-1; gastric inhibitory peptide]]></description><identifier>ISSN: 0363-6119</identifier><identifier>EISSN: 1522-1490</identifier><identifier>DOI: 10.1152/ajpregu.2000.278.2.r360</identifier><identifier>PMID: 10666136</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Appetite - drug effects ; Blood Glucose - analysis ; Catheterization ; Duodenum ; Female ; Fructose - administration & dosage ; Fructose - pharmacology ; Gastric Inhibitory Polypeptide - blood ; Gastrointestinal Motility - drug effects ; Glucagon - blood ; Glucagon-Like Peptide 1 ; Glucose - administration & dosage ; Glucose - pharmacology ; Humans ; Insulin - blood ; Intubation, Gastrointestinal ; Male ; Peptide Fragments - blood ; Pressure ; Protein Precursors - blood ; Pylorus - drug effects ; Reference Values ; Single-Blind Method</subject><ispartof>American journal of physiology. Regulatory, integrative and comparative physiology, 2000-02, Vol.278 (2), p.360-R366</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-6be583c9c877a1902749e91551d12d096f2b16fa27c1ed4e0ecb3fbb055621773</citedby><cites>FETCH-LOGICAL-c463t-6be583c9c877a1902749e91551d12d096f2b16fa27c1ed4e0ecb3fbb055621773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10666136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rayner, C. K</creatorcontrib><creatorcontrib>Park, H. S</creatorcontrib><creatorcontrib>Wishart, J. M</creatorcontrib><creatorcontrib>Kong, M.-F</creatorcontrib><creatorcontrib>Doran, S. M</creatorcontrib><creatorcontrib>Horowitz, M</creatorcontrib><title>Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans</title><title>American journal of physiology. Regulatory, integrative and comparative physiology</title><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><description><![CDATA[1 University of Adelaide Department of
Medicine, Royal Adelaide Hospital, Adelaide 5000, Australia; and
2 Department of Internal Medicine, College of
Medicine, Konkuk University, Seoul 143-130, Korea
Oral fructose empties from the stomach more rapidly and
may suppress food intake more than oral glucose. The purpose of the study was to evaluate the effects of intraduodenal infusions of fructose and glucose on antropyloric motility and appetite. Ten healthy
volunteers were given intraduodenal infusions of 25% fructose, 25%
glucose, or 0.9% saline (2 ml/min for 90 min). Antropyloric pressures,
blood glucose, and plasma insulin, gastric inhibitory peptide (GIP),
and glucagon-like peptide-1 (GLP-1) were measured concurrently; a
buffet meal was offered at the end of the infusion. Intraduodenal
fructose and glucose suppressed antral waves ( P < 0.0005 for
both), stimulated isolated pyloric pressure waves ( P < 0.05 for both), and increased basal pyloric pressure ( P = 0.10 and
P < 0.05, respectively) compared with saline, without any
significant difference between them. Intraduodenal glucose increased
blood glucose ( P < 0.0005), as well as plasma insulin ( P < 0.0005) and GIP ( P < 0.005) more
than intraduodenal fructose, whereas there was no difference in the
GLP-1 response. Intraduodenal fructose suppressed food intake compared
with saline ( P < 0.05) and glucose ( P = 0.07). We
conclude that, when infused intraduodenally at 2 kcal/min for 90 min
1 ) fructose and glucose have comparable effects on antropyloric
pressures, 2 ) fructose tends to suppress food intake more than
glucose, despite similar GLP-1 and less GIP release, and 3 )
GIP, rather than GLP-1, probably accounts for the greater insulin
response to glucose than fructose.
monosaccharides; manometry; incretins; glucagon-like peptide-1; gastric inhibitory peptide]]></description><subject>Adult</subject><subject>Appetite - drug effects</subject><subject>Blood Glucose - analysis</subject><subject>Catheterization</subject><subject>Duodenum</subject><subject>Female</subject><subject>Fructose - administration & dosage</subject><subject>Fructose - pharmacology</subject><subject>Gastric Inhibitory Polypeptide - blood</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Glucagon - blood</subject><subject>Glucagon-Like Peptide 1</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - pharmacology</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Intubation, Gastrointestinal</subject><subject>Male</subject><subject>Peptide Fragments - blood</subject><subject>Pressure</subject><subject>Protein Precursors - blood</subject><subject>Pylorus - drug effects</subject><subject>Reference Values</subject><subject>Single-Blind Method</subject><issn>0363-6119</issn><issn>1522-1490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EotvCX4CcuCX4I7HXR1S1gFSpEipny3HGG1dOHGxHkH9fL7uovXAajeZ535EehD4S3BDS0c_6cYlwWBuKMW6o2De0iYzjV2hXrrQmrcSv0Q4zzmpOiLxAlyk9FrZlLXuLLgjmnBPGdwhurAWTUxVs5eYc9bCGAWbtq4NfTUhQ6XmobFxNPi5hLnuOYdl8iM5UU8jOu7z9pfSyQHYZSlE1gvZ53KpxnfSc3qE3VvsE78_zCv28vXm4_lbf3X_9fv3lrjYtZ7nmPXR7ZqTZC6GJxFS0EiTpOjIQOmDJLe0Jt5oKQ2BoAYPpme173HWcEiHYFfp06l1i-LVCympyyYD3eoawJiXwXgqKSQHFCTQxpBTBqiW6ScdNEayOhtXZsDoaVsWwoupHMVySH84v1n6C4UXupLQA9QkY3WH87SKoZdySCz4ctufWl4Xy__zt6v0D_Mn_gs85tQyWPQEuFKDB</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Rayner, C. K</creator><creator>Park, H. S</creator><creator>Wishart, J. M</creator><creator>Kong, M.-F</creator><creator>Doran, S. M</creator><creator>Horowitz, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans</title><author>Rayner, C. K ; Park, H. S ; Wishart, J. M ; Kong, M.-F ; Doran, S. M ; Horowitz, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-6be583c9c877a1902749e91551d12d096f2b16fa27c1ed4e0ecb3fbb055621773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Appetite - drug effects</topic><topic>Blood Glucose - analysis</topic><topic>Catheterization</topic><topic>Duodenum</topic><topic>Female</topic><topic>Fructose - administration & dosage</topic><topic>Fructose - pharmacology</topic><topic>Gastric Inhibitory Polypeptide - blood</topic><topic>Gastrointestinal Motility - drug effects</topic><topic>Glucagon - blood</topic><topic>Glucagon-Like Peptide 1</topic><topic>Glucose - administration & dosage</topic><topic>Glucose - pharmacology</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Intubation, Gastrointestinal</topic><topic>Male</topic><topic>Peptide Fragments - blood</topic><topic>Pressure</topic><topic>Protein Precursors - blood</topic><topic>Pylorus - drug effects</topic><topic>Reference Values</topic><topic>Single-Blind Method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rayner, C. K</creatorcontrib><creatorcontrib>Park, H. S</creatorcontrib><creatorcontrib>Wishart, J. M</creatorcontrib><creatorcontrib>Kong, M.-F</creatorcontrib><creatorcontrib>Doran, S. M</creatorcontrib><creatorcontrib>Horowitz, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rayner, C. K</au><au>Park, H. S</au><au>Wishart, J. M</au><au>Kong, M.-F</au><au>Doran, S. M</au><au>Horowitz, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans</atitle><jtitle>American journal of physiology. Regulatory, integrative and comparative physiology</jtitle><addtitle>Am J Physiol Regul Integr Comp Physiol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>278</volume><issue>2</issue><spage>360</spage><epage>R366</epage><pages>360-R366</pages><issn>0363-6119</issn><eissn>1522-1490</eissn><abstract><![CDATA[1 University of Adelaide Department of
Medicine, Royal Adelaide Hospital, Adelaide 5000, Australia; and
2 Department of Internal Medicine, College of
Medicine, Konkuk University, Seoul 143-130, Korea
Oral fructose empties from the stomach more rapidly and
may suppress food intake more than oral glucose. The purpose of the study was to evaluate the effects of intraduodenal infusions of fructose and glucose on antropyloric motility and appetite. Ten healthy
volunteers were given intraduodenal infusions of 25% fructose, 25%
glucose, or 0.9% saline (2 ml/min for 90 min). Antropyloric pressures,
blood glucose, and plasma insulin, gastric inhibitory peptide (GIP),
and glucagon-like peptide-1 (GLP-1) were measured concurrently; a
buffet meal was offered at the end of the infusion. Intraduodenal
fructose and glucose suppressed antral waves ( P < 0.0005 for
both), stimulated isolated pyloric pressure waves ( P < 0.05 for both), and increased basal pyloric pressure ( P = 0.10 and
P < 0.05, respectively) compared with saline, without any
significant difference between them. Intraduodenal glucose increased
blood glucose ( P < 0.0005), as well as plasma insulin ( P < 0.0005) and GIP ( P < 0.005) more
than intraduodenal fructose, whereas there was no difference in the
GLP-1 response. Intraduodenal fructose suppressed food intake compared
with saline ( P < 0.05) and glucose ( P = 0.07). We
conclude that, when infused intraduodenally at 2 kcal/min for 90 min
1 ) fructose and glucose have comparable effects on antropyloric
pressures, 2 ) fructose tends to suppress food intake more than
glucose, despite similar GLP-1 and less GIP release, and 3 )
GIP, rather than GLP-1, probably accounts for the greater insulin
response to glucose than fructose.
monosaccharides; manometry; incretins; glucagon-like peptide-1; gastric inhibitory peptide]]></abstract><cop>United States</cop><pmid>10666136</pmid><doi>10.1152/ajpregu.2000.278.2.r360</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2000-02, Vol.278 (2), p.360-R366 |
| issn | 0363-6119 1522-1490 |
| language | eng |
| recordid | cdi_pubmed_primary_10666136 |
| source | MEDLINE; American Physiological Society Paid; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Appetite - drug effects Blood Glucose - analysis Catheterization Duodenum Female Fructose - administration & dosage Fructose - pharmacology Gastric Inhibitory Polypeptide - blood Gastrointestinal Motility - drug effects Glucagon - blood Glucagon-Like Peptide 1 Glucose - administration & dosage Glucose - pharmacology Humans Insulin - blood Intubation, Gastrointestinal Male Peptide Fragments - blood Pressure Protein Precursors - blood Pylorus - drug effects Reference Values Single-Blind Method |
| title | Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans |
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