Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans

1 University of Adelaide Department of Medicine, Royal Adelaide Hospital, Adelaide 5000, Australia; and 2 Department of Internal Medicine, College of Medicine, Konkuk University, Seoul 143-130, Korea Oral fructose empties from the stomach more rapidly and may suppress food intake more than oral glucose. The purpose of the study was to evaluate the effects of intraduodenal infusions of fructose and glucose on antropyloric motility and appetite. Ten healthy volunteers were given intraduodenal infusions of 25% fructose, 25% glucose, or 0.9% saline (2 ml/min for 90 min). Antropyloric pressures, blood glucose, and plasma insulin, gastric inhibitory peptide (GIP), and glucagon-like peptide-1 (GLP-1) were measured concurrently; a buffet meal was offered at the end of the infusion. Intraduodenal fructose and glucose suppressed antral waves ( P