Calcium sparks in smooth muscle
1 Department of Pharmacology, College of Medicine, The University of Vermont, Burlington, Vermont 05405; and 2 Medical Biotechnology Center, University of Maryland Biotechnology Institute, and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201 Local intr...
Gespeichert in:
| Veröffentlicht in: | American Journal of Physiology: Cell Physiology 2000-02, Vol.278 (2), p.C235-C256 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | C256 |
|---|---|
| container_issue | 2 |
| container_start_page | C235 |
| container_title | American Journal of Physiology: Cell Physiology |
| container_volume | 278 |
| creator | Jaggar, Jonathan H Porter, Valerie A Lederer, W. Jonathan Nelson, Mark T |
| description | 1 Department of Pharmacology, College of
Medicine, The University of Vermont, Burlington, Vermont 05405; and
2 Medical Biotechnology Center, University of
Maryland Biotechnology Institute, and Department of Physiology,
University of Maryland School of Medicine, Baltimore, Maryland 21201
Local intracellular Ca 2+
transients, termed Ca 2+ sparks, are caused by the
coordinated opening of a cluster of ryanodine-sensitive Ca 2+ release channels in the sarcoplasmic reticulum of
smooth muscle cells. Ca 2+ sparks are activated by
Ca 2+ entry through dihydropyridine-sensitive
voltage-dependent Ca 2+ channels, although the precise
mechanisms of communication of Ca 2+ entry to
Ca 2+ spark activation are not clear in smooth muscle.
Ca 2+ sparks act as a positive-feedback element to increase
smooth muscle contractility, directly by contributing to the global
cytoplasmic Ca 2+ concentration
([Ca 2+ ]) and indirectly by increasing
Ca 2+ entry through membrane potential depolarization,
caused by activation of Ca 2+ spark-activated
Cl channels. Ca 2+ sparks also have a
profound negative-feedback effect on contractility by decreasing
Ca 2+ entry through membrane potential hyperpolarization,
caused by activation of large-conductance, Ca 2+ -sensitive
K + channels. In this review, the roles of Ca 2+
sparks in positive- and negative-feedback regulation of smooth muscle
function are explored. We also propose that frequency and amplitude
modulation of Ca 2+ sparks by contractile and relaxant
agents is an important mechanism to regulate smooth muscle function.
ryanodine-sensitive calcium-release channel; voltage-dependent
calcium channel; calcium-sensitive potassium channel; calcium-activated
chloride channel; sarcoplasmic reticulum |
| doi_str_mv | 10.1152/ajpcell.2000.278.2.c235 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_10666018</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70904471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c517t-8377abb82c9bf1503168f04989f252bb01890662e4c830be8af0216edf3f2a483</originalsourceid><addsrcrecordid>eNp1kLtOwzAUhi0EoqXwCjQTW4JvcewRRRSQKrGU2XJcu0lxmhAngr49rlIoC9MZzn855wNgjmCCUIrv1bbVxrkEQwgTnPEEJxqT9AxMwxbHKGXkHEwhYSRmiJIJuPJ-G7QUM3EJJggyxiDiUzDPldPVUEe-Vd27j6pd5Oum6cuoHrx25hpcWOW8uTnOGXhbPK7y53j5-vSSPyxjnaKsjznJMlUUHGtRWJRCghi3kAouLE5xUYQuETqxoZoTWBiuLMSImbUlFivKyQzcjblt13wMxveyrvzhRbUzzeBlBgWkNENBmI1C3TXed8bKtqtq1e0lgvLARh7ZyAMbGdhILPPAJjhvjxVDUZv1H98IIwjEKCirTflZdUa25d5XjWs2e7kYnFuZr_4n_hQs2_DFDMT_e38vOh3zDQYqhQg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70904471</pqid></control><display><type>article</type><title>Calcium sparks in smooth muscle</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Jaggar, Jonathan H ; Porter, Valerie A ; Lederer, W. Jonathan ; Nelson, Mark T</creator><creatorcontrib>Jaggar, Jonathan H ; Porter, Valerie A ; Lederer, W. Jonathan ; Nelson, Mark T</creatorcontrib><description>1 Department of Pharmacology, College of
Medicine, The University of Vermont, Burlington, Vermont 05405; and
2 Medical Biotechnology Center, University of
Maryland Biotechnology Institute, and Department of Physiology,
University of Maryland School of Medicine, Baltimore, Maryland 21201
Local intracellular Ca 2+
transients, termed Ca 2+ sparks, are caused by the
coordinated opening of a cluster of ryanodine-sensitive Ca 2+ release channels in the sarcoplasmic reticulum of
smooth muscle cells. Ca 2+ sparks are activated by
Ca 2+ entry through dihydropyridine-sensitive
voltage-dependent Ca 2+ channels, although the precise
mechanisms of communication of Ca 2+ entry to
Ca 2+ spark activation are not clear in smooth muscle.
Ca 2+ sparks act as a positive-feedback element to increase
smooth muscle contractility, directly by contributing to the global
cytoplasmic Ca 2+ concentration
([Ca 2+ ]) and indirectly by increasing
Ca 2+ entry through membrane potential depolarization,
caused by activation of Ca 2+ spark-activated
Cl channels. Ca 2+ sparks also have a
profound negative-feedback effect on contractility by decreasing
Ca 2+ entry through membrane potential hyperpolarization,
caused by activation of large-conductance, Ca 2+ -sensitive
K + channels. In this review, the roles of Ca 2+
sparks in positive- and negative-feedback regulation of smooth muscle
function are explored. We also propose that frequency and amplitude
modulation of Ca 2+ sparks by contractile and relaxant
agents is an important mechanism to regulate smooth muscle function.
ryanodine-sensitive calcium-release channel; voltage-dependent
calcium channel; calcium-sensitive potassium channel; calcium-activated
chloride channel; sarcoplasmic reticulum</description><identifier>ISSN: 0363-6143</identifier><identifier>EISSN: 1522-1563</identifier><identifier>DOI: 10.1152/ajpcell.2000.278.2.c235</identifier><identifier>PMID: 10666018</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Calcium - metabolism ; Calcium Channels - metabolism ; Calcium Signaling - physiology ; Humans ; Muscle, Smooth - chemistry ; Muscle, Smooth - metabolism</subject><ispartof>American Journal of Physiology: Cell Physiology, 2000-02, Vol.278 (2), p.C235-C256</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-8377abb82c9bf1503168f04989f252bb01890662e4c830be8af0216edf3f2a483</citedby><cites>FETCH-LOGICAL-c517t-8377abb82c9bf1503168f04989f252bb01890662e4c830be8af0216edf3f2a483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10666018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaggar, Jonathan H</creatorcontrib><creatorcontrib>Porter, Valerie A</creatorcontrib><creatorcontrib>Lederer, W. Jonathan</creatorcontrib><creatorcontrib>Nelson, Mark T</creatorcontrib><title>Calcium sparks in smooth muscle</title><title>American Journal of Physiology: Cell Physiology</title><addtitle>Am J Physiol Cell Physiol</addtitle><description>1 Department of Pharmacology, College of
Medicine, The University of Vermont, Burlington, Vermont 05405; and
2 Medical Biotechnology Center, University of
Maryland Biotechnology Institute, and Department of Physiology,
University of Maryland School of Medicine, Baltimore, Maryland 21201
Local intracellular Ca 2+
transients, termed Ca 2+ sparks, are caused by the
coordinated opening of a cluster of ryanodine-sensitive Ca 2+ release channels in the sarcoplasmic reticulum of
smooth muscle cells. Ca 2+ sparks are activated by
Ca 2+ entry through dihydropyridine-sensitive
voltage-dependent Ca 2+ channels, although the precise
mechanisms of communication of Ca 2+ entry to
Ca 2+ spark activation are not clear in smooth muscle.
Ca 2+ sparks act as a positive-feedback element to increase
smooth muscle contractility, directly by contributing to the global
cytoplasmic Ca 2+ concentration
([Ca 2+ ]) and indirectly by increasing
Ca 2+ entry through membrane potential depolarization,
caused by activation of Ca 2+ spark-activated
Cl channels. Ca 2+ sparks also have a
profound negative-feedback effect on contractility by decreasing
Ca 2+ entry through membrane potential hyperpolarization,
caused by activation of large-conductance, Ca 2+ -sensitive
K + channels. In this review, the roles of Ca 2+
sparks in positive- and negative-feedback regulation of smooth muscle
function are explored. We also propose that frequency and amplitude
modulation of Ca 2+ sparks by contractile and relaxant
agents is an important mechanism to regulate smooth muscle function.
ryanodine-sensitive calcium-release channel; voltage-dependent
calcium channel; calcium-sensitive potassium channel; calcium-activated
chloride channel; sarcoplasmic reticulum</description><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium Channels - metabolism</subject><subject>Calcium Signaling - physiology</subject><subject>Humans</subject><subject>Muscle, Smooth - chemistry</subject><subject>Muscle, Smooth - metabolism</subject><issn>0363-6143</issn><issn>1522-1563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAUhi0EoqXwCjQTW4JvcewRRRSQKrGU2XJcu0lxmhAngr49rlIoC9MZzn855wNgjmCCUIrv1bbVxrkEQwgTnPEEJxqT9AxMwxbHKGXkHEwhYSRmiJIJuPJ-G7QUM3EJJggyxiDiUzDPldPVUEe-Vd27j6pd5Oum6cuoHrx25hpcWOW8uTnOGXhbPK7y53j5-vSSPyxjnaKsjznJMlUUHGtRWJRCghi3kAouLE5xUYQuETqxoZoTWBiuLMSImbUlFivKyQzcjblt13wMxveyrvzhRbUzzeBlBgWkNENBmI1C3TXed8bKtqtq1e0lgvLARh7ZyAMbGdhILPPAJjhvjxVDUZv1H98IIwjEKCirTflZdUa25d5XjWs2e7kYnFuZr_4n_hQs2_DFDMT_e38vOh3zDQYqhQg</recordid><startdate>20000201</startdate><enddate>20000201</enddate><creator>Jaggar, Jonathan H</creator><creator>Porter, Valerie A</creator><creator>Lederer, W. Jonathan</creator><creator>Nelson, Mark T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000201</creationdate><title>Calcium sparks in smooth muscle</title><author>Jaggar, Jonathan H ; Porter, Valerie A ; Lederer, W. Jonathan ; Nelson, Mark T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-8377abb82c9bf1503168f04989f252bb01890662e4c830be8af0216edf3f2a483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Calcium Channels - metabolism</topic><topic>Calcium Signaling - physiology</topic><topic>Humans</topic><topic>Muscle, Smooth - chemistry</topic><topic>Muscle, Smooth - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaggar, Jonathan H</creatorcontrib><creatorcontrib>Porter, Valerie A</creatorcontrib><creatorcontrib>Lederer, W. Jonathan</creatorcontrib><creatorcontrib>Nelson, Mark T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American Journal of Physiology: Cell Physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaggar, Jonathan H</au><au>Porter, Valerie A</au><au>Lederer, W. Jonathan</au><au>Nelson, Mark T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium sparks in smooth muscle</atitle><jtitle>American Journal of Physiology: Cell Physiology</jtitle><addtitle>Am J Physiol Cell Physiol</addtitle><date>2000-02-01</date><risdate>2000</risdate><volume>278</volume><issue>2</issue><spage>C235</spage><epage>C256</epage><pages>C235-C256</pages><issn>0363-6143</issn><eissn>1522-1563</eissn><abstract>1 Department of Pharmacology, College of
Medicine, The University of Vermont, Burlington, Vermont 05405; and
2 Medical Biotechnology Center, University of
Maryland Biotechnology Institute, and Department of Physiology,
University of Maryland School of Medicine, Baltimore, Maryland 21201
Local intracellular Ca 2+
transients, termed Ca 2+ sparks, are caused by the
coordinated opening of a cluster of ryanodine-sensitive Ca 2+ release channels in the sarcoplasmic reticulum of
smooth muscle cells. Ca 2+ sparks are activated by
Ca 2+ entry through dihydropyridine-sensitive
voltage-dependent Ca 2+ channels, although the precise
mechanisms of communication of Ca 2+ entry to
Ca 2+ spark activation are not clear in smooth muscle.
Ca 2+ sparks act as a positive-feedback element to increase
smooth muscle contractility, directly by contributing to the global
cytoplasmic Ca 2+ concentration
([Ca 2+ ]) and indirectly by increasing
Ca 2+ entry through membrane potential depolarization,
caused by activation of Ca 2+ spark-activated
Cl channels. Ca 2+ sparks also have a
profound negative-feedback effect on contractility by decreasing
Ca 2+ entry through membrane potential hyperpolarization,
caused by activation of large-conductance, Ca 2+ -sensitive
K + channels. In this review, the roles of Ca 2+
sparks in positive- and negative-feedback regulation of smooth muscle
function are explored. We also propose that frequency and amplitude
modulation of Ca 2+ sparks by contractile and relaxant
agents is an important mechanism to regulate smooth muscle function.
ryanodine-sensitive calcium-release channel; voltage-dependent
calcium channel; calcium-sensitive potassium channel; calcium-activated
chloride channel; sarcoplasmic reticulum</abstract><cop>United States</cop><pmid>10666018</pmid><doi>10.1152/ajpcell.2000.278.2.c235</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-6143 |
| ispartof | American Journal of Physiology: Cell Physiology, 2000-02, Vol.278 (2), p.C235-C256 |
| issn | 0363-6143 1522-1563 |
| language | eng |
| recordid | cdi_pubmed_primary_10666018 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Calcium - metabolism Calcium Channels - metabolism Calcium Signaling - physiology Humans Muscle, Smooth - chemistry Muscle, Smooth - metabolism |
| title | Calcium sparks in smooth muscle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T19%3A13%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Calcium%20sparks%20in%20smooth%20muscle&rft.jtitle=American%20Journal%20of%20Physiology:%20Cell%20Physiology&rft.au=Jaggar,%20Jonathan%20H&rft.date=2000-02-01&rft.volume=278&rft.issue=2&rft.spage=C235&rft.epage=C256&rft.pages=C235-C256&rft.issn=0363-6143&rft.eissn=1522-1563&rft_id=info:doi/10.1152/ajpcell.2000.278.2.c235&rft_dat=%3Cproquest_pubme%3E70904471%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70904471&rft_id=info:pmid/10666018&rfr_iscdi=true |