Positive and Negative Regulation of Endogenous Genes by Designed Transcription Factors

Gene regulation by imposed localization was studied by using designed zinc finger proteins that bind 18-bp DNA sequences in the 5′untranslated regions of the protooncogenes erbB-2 and erbB-3. Transcription factors were generated by fusion of the DNA-binding proteins to repression or activation domai...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-02, Vol.97 (4), p.1495-1500
Hauptverfasser:	Beerli, Roger R., Dreier, Birgit, Barbas, Carlos F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Biochemistry Biological Sciences Cell cycle Cell Cycle - genetics Cell Line Cell lines DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - pharmacology erbB-2 gene erbB-3 gene Gene expression regulation Gene Expression Regulation - drug effects Gene Targeting Genes Genes, erbB - genetics Genes, erbB-2 - genetics Genes, Reporter HeLa cells Humans Molecular Sequence Data Proteins Recombinant Fusion Proteins - pharmacology Repressor Proteins - pharmacology Retroviridae Retroviridae - genetics Trans-Activators - pharmacology Transcription factors Transcription Factors - pharmacology Transcriptional regulatory elements Transfection Zinc Fingers - genetics
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