Multiple-Drug Chemotherapy in the Management of Acute Lymphocytic Leukemia During Pregnancy
Acute leukemia associated with pregnancy is relatively uncommon, and because of the age distribution of patients with acute leukemia the majority have had acute granulocytic leukemia. Various combinations of chemotherapeutic agents are commonly employed now to obtain maximal benefit, related to diff...
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Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1976-09, Vol.48 (3), p.324-327 |
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container_title | Obstetrics and gynecology (New York. 1953) |
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creator | KRUEGER, JUDY A. DAVIS, RICHARD B. FIELD, CHARLES |
description | Acute leukemia associated with pregnancy is relatively uncommon, and because of the age distribution of patients with acute leukemia the majority have had acute granulocytic leukemia. Various combinations of chemotherapeutic agents are commonly employed now to obtain maximal benefit, related to differing pharmacologic activities of single agents. The present case documents the use of multiple cytotoxic drugs in the management of acute lymphocytic leukemia, with successful delivery of a normal infant. In this patient severe anemia and potentially teratogenic drugs did not appear to affect the fetus. |
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Various combinations of chemotherapeutic agents are commonly employed now to obtain maximal benefit, related to differing pharmacologic activities of single agents. The present case documents the use of multiple cytotoxic drugs in the management of acute lymphocytic leukemia, with successful delivery of a normal infant. In this patient severe anemia and potentially teratogenic drugs did not appear to affect the fetus.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 1065823</identifier><language>eng</language><publisher>United States: The American College of Obstetricians and Gynecologists</publisher><subject>Adolescent ; Cyclophosphamide - therapeutic use ; Delivery, Obstetric ; Drug Therapy, Combination ; Female ; Humans ; Labor, Induced ; Leukemia, Lymphoid - drug therapy ; Mercaptopurine - therapeutic use ; Methotrexate - therapeutic use ; Prednisone - therapeutic use ; Pregnancy ; Pregnancy Complications, Hematologic - drug therapy ; Vincristine - therapeutic use</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1976-09, Vol.48 (3), p.324-327</ispartof><rights>1976 The American College of Obstetricians and Gynecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1065823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRUEGER, JUDY A.</creatorcontrib><creatorcontrib>DAVIS, RICHARD B.</creatorcontrib><creatorcontrib>FIELD, CHARLES</creatorcontrib><title>Multiple-Drug Chemotherapy in the Management of Acute Lymphocytic Leukemia During Pregnancy</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Acute leukemia associated with pregnancy is relatively uncommon, and because of the age distribution of patients with acute leukemia the majority have had acute granulocytic leukemia. Various combinations of chemotherapeutic agents are commonly employed now to obtain maximal benefit, related to differing pharmacologic activities of single agents. The present case documents the use of multiple cytotoxic drugs in the management of acute lymphocytic leukemia, with successful delivery of a normal infant. In this patient severe anemia and potentially teratogenic drugs did not appear to affect the fetus.</description><subject>Adolescent</subject><subject>Cyclophosphamide - therapeutic use</subject><subject>Delivery, Obstetric</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Labor, Induced</subject><subject>Leukemia, Lymphoid - drug therapy</subject><subject>Mercaptopurine - therapeutic use</subject><subject>Methotrexate - therapeutic use</subject><subject>Prednisone - therapeutic use</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Hematologic - drug therapy</subject><subject>Vincristine - therapeutic use</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUMlqwzAUFKUlTdN-QkE_IJAlW7aOIekGDu0hh0IP5kl-XhpvyBbBf1-X5DQzDAwzc0PWQRJLJqT8viVrzoVmcRKG9-RhHH8554HSckVWAVdRIuSa_Bx8M9VDg2zvfEl3Fbb9VKGDYaZ1RxdKD9BBiS12E-0LurV-QprO7VD1dp5qS1P0J2xroHvv6q6kXw7LDjo7P5K7ApoRn664IcfXl-PunaWfbx-7bcoGEQUhE4VCawQYDsJK1DoQBjVYrXILeWxyZa02S2ETQxHFORgrFMaJtIBCW7khz5fYwZsW82xwdQtuzq4bFz-8-Oe-mdCNp8af0WUVQjNV2fIJVyLiLNCx4npR7P-mUP4BbAxgpA</recordid><startdate>197609</startdate><enddate>197609</enddate><creator>KRUEGER, JUDY A.</creator><creator>DAVIS, RICHARD B.</creator><creator>FIELD, CHARLES</creator><general>The American College of Obstetricians and Gynecologists</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197609</creationdate><title>Multiple-Drug Chemotherapy in the Management of Acute Lymphocytic Leukemia During Pregnancy</title><author>KRUEGER, JUDY A. ; DAVIS, RICHARD B. ; FIELD, CHARLES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2514-2f6ecb2ab0a2c3e9912be9ac96dcad7bd6cc9b065b7af57dabc26e783cae29c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Adolescent</topic><topic>Cyclophosphamide - therapeutic use</topic><topic>Delivery, Obstetric</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Labor, Induced</topic><topic>Leukemia, Lymphoid - drug therapy</topic><topic>Mercaptopurine - therapeutic use</topic><topic>Methotrexate - therapeutic use</topic><topic>Prednisone - therapeutic use</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Hematologic - drug therapy</topic><topic>Vincristine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRUEGER, JUDY A.</creatorcontrib><creatorcontrib>DAVIS, RICHARD B.</creatorcontrib><creatorcontrib>FIELD, CHARLES</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRUEGER, JUDY A.</au><au>DAVIS, RICHARD B.</au><au>FIELD, CHARLES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple-Drug Chemotherapy in the Management of Acute Lymphocytic Leukemia During Pregnancy</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1976-09</date><risdate>1976</risdate><volume>48</volume><issue>3</issue><spage>324</spage><epage>327</epage><pages>324-327</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><abstract>Acute leukemia associated with pregnancy is relatively uncommon, and because of the age distribution of patients with acute leukemia the majority have had acute granulocytic leukemia. Various combinations of chemotherapeutic agents are commonly employed now to obtain maximal benefit, related to differing pharmacologic activities of single agents. The present case documents the use of multiple cytotoxic drugs in the management of acute lymphocytic leukemia, with successful delivery of a normal infant. In this patient severe anemia and potentially teratogenic drugs did not appear to affect the fetus.</abstract><cop>United States</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>1065823</pmid><tpages>4</tpages></addata></record> |
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identifier | ISSN: 0029-7844 |
ispartof | Obstetrics and gynecology (New York. 1953), 1976-09, Vol.48 (3), p.324-327 |
issn | 0029-7844 1873-233X |
language | eng |
recordid | cdi_pubmed_primary_1065823 |
source | MEDLINE; Journals@Ovid Complete |
subjects | Adolescent Cyclophosphamide - therapeutic use Delivery, Obstetric Drug Therapy, Combination Female Humans Labor, Induced Leukemia, Lymphoid - drug therapy Mercaptopurine - therapeutic use Methotrexate - therapeutic use Prednisone - therapeutic use Pregnancy Pregnancy Complications, Hematologic - drug therapy Vincristine - therapeutic use |
title | Multiple-Drug Chemotherapy in the Management of Acute Lymphocytic Leukemia During Pregnancy |
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