Glycosidase Mechanisms:  Anatomy of a Finely Tuned Catalyst

In order to accelerate the hydrolysis of glycosidic bonds by factors approaching 1017-fold, glycosidases have evolved finely tuned active sites optimally configured for transition-state stabilization. Structural analyses of various enzyme complexes representing stable intermediates along the reactio...

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Veröffentlicht in:	Accounts of chemical research 2000-01, Vol.33 (1), p.11-18
Hauptverfasser:	Zechel, David L, Withers, Stephen G
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Crystallography, X-Ray Glycoside Hydrolases - chemistry Glycoside Hydrolases - genetics Glycoside Hydrolases - metabolism Hydrogen-Ion Concentration Hydrolysis Mutagenesis Protein Conformation Substrate Specificity
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