Role of Leukotrienes on Coronary Vasoconstriction in Isolated Hearts of Arthritic Rats: Effect of in vivo Treatment with CI-986, a Dual Inhibitor of Cyclooxygenase and Lipoxygenase
In this study, coronary perfusion pressure and force of contraction were investigated in isolated hearts removed from arthritic rats by using the Langendorff method. A strong coronary vasoconstriction was determined in arthritic hearts which was associated with elevated levels of arachidonate 5-lipo...
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| Veröffentlicht in: | Pharmacology 2000-01, Vol.60 (1), p.41-46 |
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| creator | Gök, Şule Ülker, Sibel Hüseyinov, Afig Hatip, Funda Bölükbaşι Çınar, Mehtap Gülcihan Evinç, Akgün |
| description | In this study, coronary perfusion pressure and force of contraction were investigated in isolated hearts removed from arthritic rats by using the Langendorff method. A strong coronary vasoconstriction was determined in arthritic hearts which was associated with elevated levels of arachidonate 5-lipoxygenase (5-LOX) products, leukotriene B 4 (LTB 4 ) and LTC 4 in coronary effluents. In vivo treatment with the dual inhibitor of cyclooxygenase (COX) and LOX, CI-986 (2 and 10 mg/kg/day) on days 14– 26 following adjuvant injection, prevented the coronary vasoconstriction and the increased production of LTB 4 and LTC 4 . These results suggest that the coronary vasoconstriction in the isolated arthritic hearts is associated with an increased activity of the LOX system and CI-986 could have a preventive effect on constriction of coronary arteries. |
| doi_str_mv | 10.1159/000028345 |
| format | Article |
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A strong coronary vasoconstriction was determined in arthritic hearts which was associated with elevated levels of arachidonate 5-lipoxygenase (5-LOX) products, leukotriene B 4 (LTB 4 ) and LTC 4 in coronary effluents. In vivo treatment with the dual inhibitor of cyclooxygenase (COX) and LOX, CI-986 (2 and 10 mg/kg/day) on days 14– 26 following adjuvant injection, prevented the coronary vasoconstriction and the increased production of LTB 4 and LTC 4 . These results suggest that the coronary vasoconstriction in the isolated arthritic hearts is associated with an increased activity of the LOX system and CI-986 could have a preventive effect on constriction of coronary arteries.</description><identifier>ISSN: 0031-7012</identifier><identifier>EISSN: 1423-0313</identifier><identifier>DOI: 10.1159/000028345</identifier><identifier>PMID: 10629442</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Arthritis, Experimental - physiopathology ; Coronary Vessels - drug effects ; Coronary Vessels - physiopathology ; Cyclooxygenase Inhibitors - pharmacology ; Heart Function Tests ; Heart Rate - drug effects ; In Vitro Techniques ; Leukotrienes - metabolism ; Leukotrienes - physiology ; Lipoxygenase Inhibitors - pharmacology ; Male ; Myocardial Contraction - drug effects ; Original Paper ; Rats ; Rats, Wistar ; Thiadiazoles - pharmacology ; Vasoconstriction - drug effects</subject><ispartof>Pharmacology, 2000-01, Vol.60 (1), p.41-46</ispartof><rights>2000 S. Karger AG, Basel</rights><rights>Copyright 2000 S. Karger AG, Basel</rights><rights>Copyright (c) 2000 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-9ecb5172bdf5c23c802e1b26c90e8aa7ab21415e7eb18e6a789a744ce8a786553</citedby><cites>FETCH-LOGICAL-c271t-9ecb5172bdf5c23c802e1b26c90e8aa7ab21415e7eb18e6a789a744ce8a786553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10629442$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gök, Şule</creatorcontrib><creatorcontrib>Ülker, Sibel</creatorcontrib><creatorcontrib>Hüseyinov, Afig</creatorcontrib><creatorcontrib>Hatip, Funda Bölükbaşι</creatorcontrib><creatorcontrib>Çınar, Mehtap Gülcihan</creatorcontrib><creatorcontrib>Evinç, Akgün</creatorcontrib><title>Role of Leukotrienes on Coronary Vasoconstriction in Isolated Hearts of Arthritic Rats: Effect of in vivo Treatment with CI-986, a Dual Inhibitor of Cyclooxygenase and Lipoxygenase</title><title>Pharmacology</title><addtitle>Pharmacology</addtitle><description>In this study, coronary perfusion pressure and force of contraction were investigated in isolated hearts removed from arthritic rats by using the Langendorff method. 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These results suggest that the coronary vasoconstriction in the isolated arthritic hearts is associated with an increased activity of the LOX system and CI-986 could have a preventive effect on constriction of coronary arteries.</description><subject>Animals</subject><subject>Arthritis, Experimental - physiopathology</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - physiopathology</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Heart Function Tests</subject><subject>Heart Rate - drug effects</subject><subject>In Vitro Techniques</subject><subject>Leukotrienes - metabolism</subject><subject>Leukotrienes - physiology</subject><subject>Lipoxygenase Inhibitors - pharmacology</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Thiadiazoles - pharmacology</subject><subject>Vasoconstriction - drug effects</subject><issn>0031-7012</issn><issn>1423-0313</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0V-L1DAQAPAgird3-uCzIEFBEKw26Z-kvi31dBcWlOP0tUzT6W3uusmapHfu9_IDmtpjETEvEzK_TMIMIc9Y-o6xonqfxsVllhcPyILlPEvSjGUPySKNMREp4yfk1PvrqEou5GNywuKmynO-IL8u7IDU9nSD440NTqNBT62htXXWgDvQ7-CtssbHnAo6ZrSha28HCNjRFYILfrq_dGHrdNCKXkDwH-h536MKUyb6W31r6aVDCDs0gd7psKX1Oqlk-ZYC_TjCQNdmq1sdrJuu1Ac1WPvzcIUGPFIwHd3o_fHgCXnUw-Dx6X08I98-nV_Wq2Tz5fO6Xm4SxQULSYWqLZjgbdcXimdKphxZy0tVpSgBBLSc5axAgS2TWIKQFYg8VzEpZFkU2Rl5PdfdO_tjRB-anfYKhwEM2tE3IpWF4JxH-OofeG1HZ-Lfmtjqiudcikm9mZVy1nuHfbN3ehd7HFEzDbI5DjLaF_cVx3aH3V9ynlwEL2dwA-4K3RF8XS3_VGj2XR_R8_-i-Y3fWzmt1Q</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Gök, Şule</creator><creator>Ülker, Sibel</creator><creator>Hüseyinov, Afig</creator><creator>Hatip, Funda Bölükbaşι</creator><creator>Çınar, Mehtap Gülcihan</creator><creator>Evinç, Akgün</creator><general>S. 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A strong coronary vasoconstriction was determined in arthritic hearts which was associated with elevated levels of arachidonate 5-lipoxygenase (5-LOX) products, leukotriene B 4 (LTB 4 ) and LTC 4 in coronary effluents. In vivo treatment with the dual inhibitor of cyclooxygenase (COX) and LOX, CI-986 (2 and 10 mg/kg/day) on days 14– 26 following adjuvant injection, prevented the coronary vasoconstriction and the increased production of LTB 4 and LTC 4 . These results suggest that the coronary vasoconstriction in the isolated arthritic hearts is associated with an increased activity of the LOX system and CI-986 could have a preventive effect on constriction of coronary arteries.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>10629442</pmid><doi>10.1159/000028345</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pharmacology, 2000-01, Vol.60 (1), p.41-46 |
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| source | MEDLINE; Karger Journals |
| subjects | Animals Arthritis, Experimental - physiopathology Coronary Vessels - drug effects Coronary Vessels - physiopathology Cyclooxygenase Inhibitors - pharmacology Heart Function Tests Heart Rate - drug effects In Vitro Techniques Leukotrienes - metabolism Leukotrienes - physiology Lipoxygenase Inhibitors - pharmacology Male Myocardial Contraction - drug effects Original Paper Rats Rats, Wistar Thiadiazoles - pharmacology Vasoconstriction - drug effects |
| title | Role of Leukotrienes on Coronary Vasoconstriction in Isolated Hearts of Arthritic Rats: Effect of in vivo Treatment with CI-986, a Dual Inhibitor of Cyclooxygenase and Lipoxygenase |
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