$In vivo fluence rate and fractionation effects on tumor response and photobleaching : Photodynamic therapy with two photosensitizers in an orthotopic rat tumor model$

In vivo fluence rate and fractionation effects on tumor response and photobleaching : Photodynamic therapy with two photosensitizers in an orthotopic rat tumor model

The effect of fluence rate and light fractionation on phototoxicity was investigated in vivo in an orthotopic rat bladder tumor model. Two photosensitizers, benzoporphyrin derivative monoacid ring A and 5-aminolevulinic acid-induced protoporphyrin IX, were studied. For a given cumulative light dose...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-12, Vol.59 (24), p.6164-6170
Hauptverfasser:	IINUMA, S, SCHOMACKER, K. T, WAGNIERES, G, RAJADHYAKSHA, M, BAMBERG, M, MOMMA, T, HASAN, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminolevulinic Acid - therapeutic use Animals Biological and medical sciences Dermatitis, Phototoxic Disease Models, Animal Diseases of the urinary system Female Light Medical sciences Microscopy, Fluorescence Neoplasm Transplantation Niacinamide - pharmacology Photochemotherapy Photosensitizing Agents - adverse effects Photosensitizing Agents - therapeutic use Porphyrins - therapeutic use Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Inbred F344 Spectrometry, Fluorescence Tumor Cells, Cultured Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology
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