Prophylactic DNA Vaccine for Hepatitis C Virus (HCV) Infection: HCV-Specific Cytotoxic T Lymphocyte Induction and Protection from HCV-Recombinant Vaccinia Infection in an HLA-A2.1 Transgenic Mouse Model

DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a small-animal model using HLA-A2.1-transgenic mice to test induction of HLA-A2.1-restricted cytotoxic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-01, Vol.97 (1), p.297-302
Hauptverfasser:	Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., Feinstone, Stephen M., Berzofsky, Jay A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - immunology Biological Sciences CD8-Positive T-Lymphocytes - immunology Cytotoxicity Tests, Immunologic DNA vaccines Epitopes Female Hepacivirus - genetics Hepacivirus - immunology hepatitis C virus Hepatitis, Animal - immunology histocompatibility antigen HLA HLA-A2 Antigen - immunology Humans Immunization Infections Mice Mice, Transgenic Molecules Nucleocapsid - genetics Nucleocapsid - immunology Ovary - immunology Spleen cells T lymphocytes T-Lymphocytes, Cytotoxic - immunology Vaccination Vaccines, DNA - immunology Vaccinia - genetics Viruses
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