Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men
Exercise Biochemistry Laboratory, Department of Health and Human Performance, Iowa State University, Ames, Iowa 50011 This study examined the effects of acute dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and the effect of chronic DHEA intake on the adaptations to resistance trai...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1999-12, Vol.87 (6), p.2274-2283 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Brown, Gregory A Vukovich, Matthew D Sharp, Rick L Reifenrath, Tracy A Parsons, Kerry A King, Douglas S |
| description | Exercise Biochemistry Laboratory, Department of Health and Human
Performance, Iowa State University, Ames, Iowa 50011
This study examined the effects of acute
dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and
the effect of chronic DHEA intake on the adaptations to resistance
training. In 10 young men (23 ± 4 yr old), ingestion of 50 mg of
DHEA increased serum androstenedione concentrations 150% within 60 min
( P |
| doi_str_mv | 10.1152/jappl.1999.87.6.2274 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_10601178</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>47712903</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-3bfe297cc9cf56d3441cd6670252590e01edc315f5a13da829fa087a868100453</originalsourceid><addsrcrecordid>eNp1kF1rFDEUhgdR7Fr9ByJBRLyZMScz-ZjL0m6tUPCmXkpIM8lultlkTDLU_ffNuItf4LnJgTzvOYenql4DbgAo-bhT0zQ20Pd9I3jDGkJ496RalS9SA8PwtFoJTnHNqeBn1YuUdhhD11F4Xp0BLgBwsaq-ra01OqNgUYhqRFc36wsUPEomznuUTcohZRODN0j5AalBTVllF3xCOaBokktZeW1Qjsp55zfIeXQIc2n2xr-snlk1JvPq9J5XX6_Xd5c39e2XT58vL25rTdsu1-29NaTnWvfaUja0XQd6YIxjQgntscFgBt0CtVRBOyhBequw4EowARh3tD2v3h_nTjF8n8vRcu-SNuOovAlzkqxvWQ-CFfDtP-AuzNGX2yQpBRQAF6g7QjqGlKKxcopur-JBApaLe_nTvVzcS8Elk4v7Entzmj3f783wR-gouwDvToBKWo02FnEu_eYI6SmFgn04Ylu32T64aOS0PSQXxrA5LJv_Wtn9H72ex_HO_MhL5ldEToNtHwGpPq4P</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222215110</pqid></control><display><type>article</type><title>Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Brown, Gregory A ; Vukovich, Matthew D ; Sharp, Rick L ; Reifenrath, Tracy A ; Parsons, Kerry A ; King, Douglas S</creator><creatorcontrib>Brown, Gregory A ; Vukovich, Matthew D ; Sharp, Rick L ; Reifenrath, Tracy A ; Parsons, Kerry A ; King, Douglas S</creatorcontrib><description>Exercise Biochemistry Laboratory, Department of Health and Human
Performance, Iowa State University, Ames, Iowa 50011
This study examined the effects of acute
dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and
the effect of chronic DHEA intake on the adaptations to resistance
training. In 10 young men (23 ± 4 yr old), ingestion of 50 mg of
DHEA increased serum androstenedione concentrations 150% within 60 min
( P < 0.05) but did not affect serum
testosterone and estrogen concentrations. An additional 19 men (23 ± 1 yr old) participated in an 8-wk whole body resistance-training
program and ingested DHEA (150 mg/day, n = 9) or placebo
( n = 10) during weeks
1, 2, 4, 5, 7 , and 8 . Serum androstenedione concentrations were significantly
( P < 0.05) increased in the
DHEA-treated group after 2 and 5 wk. Serum concentrations of free and
total testosterone, estrone, estradiol, estriol, lipids, and liver
transaminases were unaffected by supplementation and training, while
strength and lean body mass increased significantly and similarly
( P < 0.05) in the men treated with
placebo and DHEA. These results suggest that DHEA ingestion does not
enhance serum testosterone concentrations or adaptations associated
with resistance training in young men.
insulin; liver transaminases; serum lipids; serum estrogens; strength training</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.87.6.2274</identifier><identifier>PMID: 10601178</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Adaptation, Physiological - drug effects ; Administration, Oral ; Adult ; Anthropometry ; Biological and medical sciences ; Dehydroepiandrosterone - pharmacology ; Diet ; Double-Blind Method ; Glucose Tolerance Test ; Histocytochemistry ; Hormones ; Hormones - blood ; Hormones. Endocrine system ; Humans ; Insulin ; Insulin - blood ; Lipids ; Liver ; Male ; Medical sciences ; Men ; Muscle, Skeletal - enzymology ; Muscle, Skeletal - physiology ; Pharmacology. Drug treatments ; Physical Education and Training ; Space life sciences ; Sports training ; Steroids ; Testosterone - blood ; Weight Lifting - physiology</subject><ispartof>Journal of applied physiology (1985), 1999-12, Vol.87 (6), p.2274-2283</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society Dec 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-3bfe297cc9cf56d3441cd6670252590e01edc315f5a13da829fa087a868100453</citedby><cites>FETCH-LOGICAL-c534t-3bfe297cc9cf56d3441cd6670252590e01edc315f5a13da829fa087a868100453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3026,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1229551$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10601178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Gregory A</creatorcontrib><creatorcontrib>Vukovich, Matthew D</creatorcontrib><creatorcontrib>Sharp, Rick L</creatorcontrib><creatorcontrib>Reifenrath, Tracy A</creatorcontrib><creatorcontrib>Parsons, Kerry A</creatorcontrib><creatorcontrib>King, Douglas S</creatorcontrib><title>Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Exercise Biochemistry Laboratory, Department of Health and Human
Performance, Iowa State University, Ames, Iowa 50011
This study examined the effects of acute
dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and
the effect of chronic DHEA intake on the adaptations to resistance
training. In 10 young men (23 ± 4 yr old), ingestion of 50 mg of
DHEA increased serum androstenedione concentrations 150% within 60 min
( P < 0.05) but did not affect serum
testosterone and estrogen concentrations. An additional 19 men (23 ± 1 yr old) participated in an 8-wk whole body resistance-training
program and ingested DHEA (150 mg/day, n = 9) or placebo
( n = 10) during weeks
1, 2, 4, 5, 7 , and 8 . Serum androstenedione concentrations were significantly
( P < 0.05) increased in the
DHEA-treated group after 2 and 5 wk. Serum concentrations of free and
total testosterone, estrone, estradiol, estriol, lipids, and liver
transaminases were unaffected by supplementation and training, while
strength and lean body mass increased significantly and similarly
( P < 0.05) in the men treated with
placebo and DHEA. These results suggest that DHEA ingestion does not
enhance serum testosterone concentrations or adaptations associated
with resistance training in young men.
insulin; liver transaminases; serum lipids; serum estrogens; strength training</description><subject>Adaptation, Physiological - drug effects</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Dehydroepiandrosterone - pharmacology</subject><subject>Diet</subject><subject>Double-Blind Method</subject><subject>Glucose Tolerance Test</subject><subject>Histocytochemistry</subject><subject>Hormones</subject><subject>Hormones - blood</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Lipids</subject><subject>Liver</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Muscle, Skeletal - enzymology</subject><subject>Muscle, Skeletal - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Education and Training</subject><subject>Space life sciences</subject><subject>Sports training</subject><subject>Steroids</subject><subject>Testosterone - blood</subject><subject>Weight Lifting - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1rFDEUhgdR7Fr9ByJBRLyZMScz-ZjL0m6tUPCmXkpIM8lultlkTDLU_ffNuItf4LnJgTzvOYenql4DbgAo-bhT0zQ20Pd9I3jDGkJ496RalS9SA8PwtFoJTnHNqeBn1YuUdhhD11F4Xp0BLgBwsaq-ra01OqNgUYhqRFc36wsUPEomznuUTcohZRODN0j5AalBTVllF3xCOaBokktZeW1Qjsp55zfIeXQIc2n2xr-snlk1JvPq9J5XX6_Xd5c39e2XT58vL25rTdsu1-29NaTnWvfaUja0XQd6YIxjQgntscFgBt0CtVRBOyhBequw4EowARh3tD2v3h_nTjF8n8vRcu-SNuOovAlzkqxvWQ-CFfDtP-AuzNGX2yQpBRQAF6g7QjqGlKKxcopur-JBApaLe_nTvVzcS8Elk4v7Entzmj3f783wR-gouwDvToBKWo02FnEu_eYI6SmFgn04Ylu32T64aOS0PSQXxrA5LJv_Wtn9H72ex_HO_MhL5ldEToNtHwGpPq4P</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Brown, Gregory A</creator><creator>Vukovich, Matthew D</creator><creator>Sharp, Rick L</creator><creator>Reifenrath, Tracy A</creator><creator>Parsons, Kerry A</creator><creator>King, Douglas S</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men</title><author>Brown, Gregory A ; Vukovich, Matthew D ; Sharp, Rick L ; Reifenrath, Tracy A ; Parsons, Kerry A ; King, Douglas S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-3bfe297cc9cf56d3441cd6670252590e01edc315f5a13da829fa087a868100453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adaptation, Physiological - drug effects</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Dehydroepiandrosterone - pharmacology</topic><topic>Diet</topic><topic>Double-Blind Method</topic><topic>Glucose Tolerance Test</topic><topic>Histocytochemistry</topic><topic>Hormones</topic><topic>Hormones - blood</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Lipids</topic><topic>Liver</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Muscle, Skeletal - enzymology</topic><topic>Muscle, Skeletal - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Education and Training</topic><topic>Space life sciences</topic><topic>Sports training</topic><topic>Steroids</topic><topic>Testosterone - blood</topic><topic>Weight Lifting - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, Gregory A</creatorcontrib><creatorcontrib>Vukovich, Matthew D</creatorcontrib><creatorcontrib>Sharp, Rick L</creatorcontrib><creatorcontrib>Reifenrath, Tracy A</creatorcontrib><creatorcontrib>Parsons, Kerry A</creatorcontrib><creatorcontrib>King, Douglas S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, Gregory A</au><au>Vukovich, Matthew D</au><au>Sharp, Rick L</au><au>Reifenrath, Tracy A</au><au>Parsons, Kerry A</au><au>King, Douglas S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>87</volume><issue>6</issue><spage>2274</spage><epage>2283</epage><pages>2274-2283</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Exercise Biochemistry Laboratory, Department of Health and Human
Performance, Iowa State University, Ames, Iowa 50011
This study examined the effects of acute
dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and
the effect of chronic DHEA intake on the adaptations to resistance
training. In 10 young men (23 ± 4 yr old), ingestion of 50 mg of
DHEA increased serum androstenedione concentrations 150% within 60 min
( P < 0.05) but did not affect serum
testosterone and estrogen concentrations. An additional 19 men (23 ± 1 yr old) participated in an 8-wk whole body resistance-training
program and ingested DHEA (150 mg/day, n = 9) or placebo
( n = 10) during weeks
1, 2, 4, 5, 7 , and 8 . Serum androstenedione concentrations were significantly
( P < 0.05) increased in the
DHEA-treated group after 2 and 5 wk. Serum concentrations of free and
total testosterone, estrone, estradiol, estriol, lipids, and liver
transaminases were unaffected by supplementation and training, while
strength and lean body mass increased significantly and similarly
( P < 0.05) in the men treated with
placebo and DHEA. These results suggest that DHEA ingestion does not
enhance serum testosterone concentrations or adaptations associated
with resistance training in young men.
insulin; liver transaminases; serum lipids; serum estrogens; strength training</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10601178</pmid><doi>10.1152/jappl.1999.87.6.2274</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of applied physiology (1985), 1999-12, Vol.87 (6), p.2274-2283 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_10601178 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adaptation, Physiological - drug effects Administration, Oral Adult Anthropometry Biological and medical sciences Dehydroepiandrosterone - pharmacology Diet Double-Blind Method Glucose Tolerance Test Histocytochemistry Hormones Hormones - blood Hormones. Endocrine system Humans Insulin Insulin - blood Lipids Liver Male Medical sciences Men Muscle, Skeletal - enzymology Muscle, Skeletal - physiology Pharmacology. Drug treatments Physical Education and Training Space life sciences Sports training Steroids Testosterone - blood Weight Lifting - physiology |
| title | Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men |
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