Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in Swiss 3T3 cells

Thrombin stimulates both DNA synthesis and cell morphological changes in Swiss 3T3 cells, although the mechanism of signal coordination leading to these responses is unknown. We report here that nitric oxide (NO) donors selectively enhance thrombin-stimulated p70(S6k) activity by 40-60%, an effect t...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-12, Vol.266 (2), p.352
Hauptverfasser:	Berven, L A, Frew, I J, Crouch, M F
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Calcium Signaling Cell Movement - drug effects Cell Size - drug effects Cyclic GMP-Dependent Protein Kinases - metabolism Enzyme Activation - drug effects Mice Microscopy, Fluorescence Microscopy, Phase-Contrast Molsidomine - pharmacology Nitric Oxide - pharmacology Nitroprusside - pharmacology Phalloidine Ribosomal Protein S6 Kinases - metabolism Thrombin - pharmacology Vasodilator Agents - pharmacology
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