Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation

Zerumbone was isolated from the rhizomes of Zingiber zerumbet Smith as a potent inhibitor of tumor promoter 12-0-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. The 1C50 value of zerumbone (0.14 mu-m) is noticeably lower than those of the anti-tumor promoters we have hitherto...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1999-10, Vol.63 (10), p.1811-1812
Hauptverfasser:	Murakami, A. (Kinki Univ., Higashiosaka, Osaka (Japan)), Takahashi, M, Jiwajinda, S, Koshimizu, K, Ohigashi, H
Format:	Artikel
Sprache:	eng
Schlagworte:	AGENTES ANTINEOPLASTICOS anti-tumor promoter Anticarcinogenic Agents - chemistry Anticarcinogenic Agents - isolation & purification Anticarcinogenic Agents - pharmacology ANTINEOPLASTIC AGENTS ANTIVIRAL ANTIVIRAL AGENTS Biological and medical sciences Cell Survival - drug effects chemoprevention Drug Screening Assays, Antitumor Epstein-Barr virus General pharmacology Herpesvirus 4, Human - growth & development Humans IDENTIFICACION IDENTIFICATION INHIBICION INHIBITION Inhibitory Concentration 50 Kinetics Medical sciences MEDICAMENT CYTOSTATIQUE Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts Plants, Medicinal Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology SESQUITERPENOIDE SESQUITERPENOIDS SESQUITERPENOS Tetradecanoylphorbol Acetate - antagonists & inhibitors Tetradecanoylphorbol Acetate - pharmacology Tumor Cells, Cultured VIRICIDAS Virus Activation - drug effects zerumbone ZINGIBER Zingiber zerumbet Zingiberales - chemistry
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