p90(RSK) blocks bad-mediated cell death via a protein kinase C-dependent pathway

Although activation of protein kinase C (PKC) is known to promote cell survival and protect against cell death, the PKC targets and pathways that serve this function have remained elusive. Here we demonstrate that two potent activators of PKC, 12-O-tetradecanoylphorbol-13-acetate and bryostatin, bot...

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Veröffentlicht in:	The Journal of biological chemistry 1999-12, Vol.274 (49), p.34859
Hauptverfasser:	Tan, Y, Ruan, H, Demeter, M R, Comb, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis bcl-Associated Death Protein Bryostatins Carrier Proteins - metabolism Cell Line COS Cells Enzyme Activators - pharmacology Enzyme Inhibitors - pharmacology Humans Lactones - pharmacology Macrolides Phosphorylation - drug effects Protein Isoforms Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Recombinant Fusion Proteins - metabolism Ribosomal Protein S6 Kinases - genetics Ribosomal Protein S6 Kinases - metabolism Serine - metabolism Signal Transduction - drug effects Tetradecanoylphorbol Acetate - pharmacology Time Factors Transfection
Online-Zugang:	Volltext
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