Detection of Neuritic Plaques in Alzheimer's Disease by Magnetic Resonance Microscopy

Magnetic resonance microscopy (MRM) theoretically provides the spatial resolution and signal-to-noise ratio needed to resolve neuritic plaques, the neuropathological hallmark of Alzheimer's disease (AD). Two previously unexplored MR contrast parameters, T2* and diffusion, are tested for plaque-...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-11, Vol.96 (24), p.14079-14084
Hauptverfasser:	Benveniste, Helene, Einstein, Gillian, Kim, Katie R., Hulette, Christine, Johnson, G. Allan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over alveus Alzheimer Disease - pathology Alzheimer's disease Amyloid plaque Biological Sciences Brain Coloring Agents Dentate gyrus fimbria Histology Humans Imaging Magnetic fields Magnetic Resonance Imaging - methods magnetic resonance microscopy Microscopy Middle Aged neuritic plaques Neurology NMR Nuclear magnetic resonance Plaque, Amyloid - pathology Protons Spatial resolution Specimens Supernova remnants
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