Heme Metabolism and Lipid Peroxidation in Rat Kidney Hexachlorobenzene–Induced Porphyria: A Compartmentalized Study of Biochemical Pathogenic Mechanisms
In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, u...
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| Veröffentlicht in: | Kidney & blood pressure research 2000-01, Vol.23 (1), p.20-26 |
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| creator | Fernández-Tomé, María del Carmen Billi de Catabbi, Silvia C. Aldonatti, Carmen San Martin de Viale, Leonor C. Sterin-Speziale, Norma B. |
| description | In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen decarboxylase activity, and its inhibitor formation, as measures of heme metabolism, were determined in renal cortex, medulla, and papilla. Adult Wistar rats were treated with HCB during 1, 2, 3, or 4 weeks. A significant increase in cortical conjugated dienes was observed from the 1st week of treatment. The malondialdehyde levels rose by 47, 34, and 28% after 2, 3, and 4 weeks of intoxication, respectively. The porphyrin content showed a tenfold increase after 4 weeks of treatment, and the uroporphyrinogen decarboxylase activity was reduced by 26 and 58% with respect to control values after 3 and 4 weeks of treatment, respectively. The results demonstrate a direct correlation between the oxidative environment and the effect elicited by the drug on heme metabolism in the renal cortex. In contrast, in papilla and medulla, where the antioxidant systems were higher, HCB showed no porphyrinogenic effect. |
| doi_str_mv | 10.1159/000025950 |
| format | Article |
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For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen decarboxylase activity, and its inhibitor formation, as measures of heme metabolism, were determined in renal cortex, medulla, and papilla. Adult Wistar rats were treated with HCB during 1, 2, 3, or 4 weeks. A significant increase in cortical conjugated dienes was observed from the 1st week of treatment. The malondialdehyde levels rose by 47, 34, and 28% after 2, 3, and 4 weeks of intoxication, respectively. The porphyrin content showed a tenfold increase after 4 weeks of treatment, and the uroporphyrinogen decarboxylase activity was reduced by 26 and 58% with respect to control values after 3 and 4 weeks of treatment, respectively. The results demonstrate a direct correlation between the oxidative environment and the effect elicited by the drug on heme metabolism in the renal cortex. In contrast, in papilla and medulla, where the antioxidant systems were higher, HCB showed no porphyrinogenic effect.</description><identifier>ISSN: 1420-4096</identifier><identifier>EISSN: 1423-0143</identifier><identifier>DOI: 10.1159/000025950</identifier><identifier>PMID: 10567850</identifier><identifier>CODEN: RPBIEL</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Animals ; Biomarkers ; Enzyme Inhibitors - pharmacology ; Female ; Heme - metabolism ; Hexachlorobenzene - toxicity ; Kidney - cytology ; Kidney - drug effects ; Kidney Cortex - metabolism ; Lipid Peroxidation - drug effects ; Liver - metabolism ; Malondialdehyde - metabolism ; Original Paper ; Porphyrias - chemically induced ; Porphyrias - metabolism ; Porphyrins - metabolism ; Rats ; Rats, Wistar ; Uroporphyrinogen Decarboxylase - antagonists & inhibitors ; Uroporphyrinogen Decarboxylase - metabolism</subject><ispartof>Kidney & blood pressure research, 2000-01, Vol.23 (1), p.20-26</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-1ded70eca92e0afa81a331b8e75dd2a4b5d18b43eccced95bd464e59cbd71c653</citedby><cites>FETCH-LOGICAL-c355t-1ded70eca92e0afa81a331b8e75dd2a4b5d18b43eccced95bd464e59cbd71c653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10567850$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-Tomé, María del Carmen</creatorcontrib><creatorcontrib>Billi de Catabbi, Silvia C.</creatorcontrib><creatorcontrib>Aldonatti, Carmen</creatorcontrib><creatorcontrib>San Martin de Viale, Leonor C.</creatorcontrib><creatorcontrib>Sterin-Speziale, Norma B.</creatorcontrib><title>Heme Metabolism and Lipid Peroxidation in Rat Kidney Hexachlorobenzene–Induced Porphyria: A Compartmentalized Study of Biochemical Pathogenic Mechanisms</title><title>Kidney & blood pressure research</title><addtitle>Kidney Blood Press Res</addtitle><description>In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen decarboxylase activity, and its inhibitor formation, as measures of heme metabolism, were determined in renal cortex, medulla, and papilla. Adult Wistar rats were treated with HCB during 1, 2, 3, or 4 weeks. A significant increase in cortical conjugated dienes was observed from the 1st week of treatment. The malondialdehyde levels rose by 47, 34, and 28% after 2, 3, and 4 weeks of intoxication, respectively. The porphyrin content showed a tenfold increase after 4 weeks of treatment, and the uroporphyrinogen decarboxylase activity was reduced by 26 and 58% with respect to control values after 3 and 4 weeks of treatment, respectively. The results demonstrate a direct correlation between the oxidative environment and the effect elicited by the drug on heme metabolism in the renal cortex. In contrast, in papilla and medulla, where the antioxidant systems were higher, HCB showed no porphyrinogenic effect.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Heme - metabolism</subject><subject>Hexachlorobenzene - toxicity</subject><subject>Kidney - cytology</subject><subject>Kidney - drug effects</subject><subject>Kidney Cortex - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - metabolism</subject><subject>Malondialdehyde - metabolism</subject><subject>Original Paper</subject><subject>Porphyrias - chemically induced</subject><subject>Porphyrias - metabolism</subject><subject>Porphyrins - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Uroporphyrinogen Decarboxylase - antagonists & inhibitors</subject><subject>Uroporphyrinogen Decarboxylase - metabolism</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc1O3DAUhS1UVP666LpSZXXHImAn9sykOxgBg5gKxM86urFviCGxU8eRGFa8AzsejyfBMIiyqDe2dD-fc3QPId852-Fc5rssnlTmkq2QdS7SLGFcZF_e3iwRLB-tkY2-v4mUjOBXssaZHI0nkq2Tpxm2SP9ggNI1pm8pWE3npjOanqF3d0ZDMM5SY-k5BHpitMUFneEdqLpx3pVo79Hi88PjsdWDwvjN-a5eeAO_6R6durYDH1q0ARpzH8cXYdAL6iq6b5yqsTUKGnoGoXbXaI2KUVQNNibpt8hqBU2P397vTXJ1eHA5nSXz06Pj6d48UZmUIeEa9ZihgjxFBhVMOGQZLyc4llqnIEqp-aQUGSoV4-Wy1GIkUOaq1GOuRjLbJL-Wup13fwfsQ3HjBm-jZZGmgnMh0zxC20tIedf3Hqui86YFvyg4K15LKD5KiOzPd8GhbFF_Ipdb_-d4C_4a_Qdwsn_-plB0uorQj_9CS48XakSaaw</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Fernández-Tomé, María del Carmen</creator><creator>Billi de Catabbi, Silvia C.</creator><creator>Aldonatti, Carmen</creator><creator>San Martin de Viale, Leonor C.</creator><creator>Sterin-Speziale, Norma B.</creator><general>S. 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Billi de Catabbi, Silvia C. ; Aldonatti, Carmen ; San Martin de Viale, Leonor C. ; Sterin-Speziale, Norma B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-1ded70eca92e0afa81a331b8e75dd2a4b5d18b43eccced95bd464e59cbd71c653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Heme - metabolism</topic><topic>Hexachlorobenzene - toxicity</topic><topic>Kidney - cytology</topic><topic>Kidney - drug effects</topic><topic>Kidney Cortex - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - metabolism</topic><topic>Malondialdehyde - metabolism</topic><topic>Original Paper</topic><topic>Porphyrias - chemically induced</topic><topic>Porphyrias - metabolism</topic><topic>Porphyrins - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Uroporphyrinogen Decarboxylase - antagonists & inhibitors</topic><topic>Uroporphyrinogen Decarboxylase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-Tomé, María del Carmen</creatorcontrib><creatorcontrib>Billi de Catabbi, Silvia C.</creatorcontrib><creatorcontrib>Aldonatti, Carmen</creatorcontrib><creatorcontrib>San Martin de Viale, Leonor C.</creatorcontrib><creatorcontrib>Sterin-Speziale, Norma B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><jtitle>Kidney & blood pressure research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-Tomé, María del Carmen</au><au>Billi de Catabbi, Silvia C.</au><au>Aldonatti, Carmen</au><au>San Martin de Viale, Leonor C.</au><au>Sterin-Speziale, Norma B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heme Metabolism and Lipid Peroxidation in Rat Kidney Hexachlorobenzene–Induced Porphyria: A Compartmentalized Study of Biochemical Pathogenic Mechanisms</atitle><jtitle>Kidney & blood pressure research</jtitle><addtitle>Kidney Blood Press Res</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>23</volume><issue>1</issue><spage>20</spage><epage>26</epage><pages>20-26</pages><issn>1420-4096</issn><eissn>1423-0143</eissn><coden>RPBIEL</coden><abstract>In the present study, the effects of hexachlorobenzene (HCB) on lipid peroxidation and heme metabolism in the different constitutive suborgans of the kidney were determined. For this purpose, conjugated diene and malondialdehyde levels, as lipid peroxidation parameters, and porphyrin accumulation, uroporphyrinogen decarboxylase activity, and its inhibitor formation, as measures of heme metabolism, were determined in renal cortex, medulla, and papilla. Adult Wistar rats were treated with HCB during 1, 2, 3, or 4 weeks. A significant increase in cortical conjugated dienes was observed from the 1st week of treatment. The malondialdehyde levels rose by 47, 34, and 28% after 2, 3, and 4 weeks of intoxication, respectively. The porphyrin content showed a tenfold increase after 4 weeks of treatment, and the uroporphyrinogen decarboxylase activity was reduced by 26 and 58% with respect to control values after 3 and 4 weeks of treatment, respectively. The results demonstrate a direct correlation between the oxidative environment and the effect elicited by the drug on heme metabolism in the renal cortex. In contrast, in papilla and medulla, where the antioxidant systems were higher, HCB showed no porphyrinogenic effect.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>10567850</pmid><doi>10.1159/000025950</doi><tpages>7</tpages></addata></record> |
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| ispartof | Kidney & blood pressure research, 2000-01, Vol.23 (1), p.20-26 |
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| subjects | Animals Biomarkers Enzyme Inhibitors - pharmacology Female Heme - metabolism Hexachlorobenzene - toxicity Kidney - cytology Kidney - drug effects Kidney Cortex - metabolism Lipid Peroxidation - drug effects Liver - metabolism Malondialdehyde - metabolism Original Paper Porphyrias - chemically induced Porphyrias - metabolism Porphyrins - metabolism Rats Rats, Wistar Uroporphyrinogen Decarboxylase - antagonists & inhibitors Uroporphyrinogen Decarboxylase - metabolism |
| title | Heme Metabolism and Lipid Peroxidation in Rat Kidney Hexachlorobenzene–Induced Porphyria: A Compartmentalized Study of Biochemical Pathogenic Mechanisms |
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