Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure
Departments of 1 Physiology and 2 Pathology, University of South Alabama, Mobile, Alabama 36688; 3 Department of Physiology, University of Bergen, Bergen, Norway; and 4 Department of Medicine, University of California, San Diego, La Jolla, California 92103 We previously showed that pacing-induce...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1999-11, Vol.87 (5), p.1823-1830 |
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| container_title | Journal of applied physiology (1985) |
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| creator | Townsley, Mary I Snell, Kenneth S Ivey, Claire L Culberson, Donald E Liu, Da Chang Reed, Rolf K Mathieu-Costello, Odile |
| description | Departments of 1 Physiology and
2 Pathology, University of South
Alabama, Mobile, Alabama 36688;
3 Department of Physiology,
University of Bergen, Bergen, Norway; and
4 Department of Medicine,
University of California, San Diego, La Jolla, California 92103
We previously showed that pacing-induced heart
failure in dogs results in an enhancement of pulmonary vascular
reactivity. In the present study we hypothesized that enhanced matrix
deposition and structural remodeling of lung resistance
microvessels would underlie these functional changes. Using
biochemical measures, we found no difference in the normalized lung
content of hyaluronan, uronic acid, and collagen between control dogs
and dogs paced for 1 mo, although lung dry weight and noncollagen
protein content increased significantly in the paced group
( P |
| doi_str_mv | 10.1152/jappl.1999.87.5.1823 |
| format | Article |
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2 Pathology, University of South
Alabama, Mobile, Alabama 36688;
3 Department of Physiology,
University of Bergen, Bergen, Norway; and
4 Department of Medicine,
University of California, San Diego, La Jolla, California 92103
We previously showed that pacing-induced heart
failure in dogs results in an enhancement of pulmonary vascular
reactivity. In the present study we hypothesized that enhanced matrix
deposition and structural remodeling of lung resistance
microvessels would underlie these functional changes. Using
biochemical measures, we found no difference in the normalized lung
content of hyaluronan, uronic acid, and collagen between control dogs
and dogs paced for 1 mo, although lung dry weight and noncollagen
protein content increased significantly in the paced group
( P < 0.05). From separate Formalin-fixed lung lobes, 5-µm frozen sections were prepared and
stained with Masson's trichrome, and vascular structure was evaluated
using standard morphometric techniques. When perivascular fluid cuffs
were excluded from the measure of wall thickness, collagen and media
volume fractions in any size range did not differ between paced and
control groups. Similarly, in the paced group, medial thickness in
<400-µm arterial or venular microvessels did not vary significantly
from that in the controls. In contrast, the relationship of
interstitial fluid pressure to lung water was significantly shifted to
the right in the paced group, such that normal tissue pressures were
observed, despite the increased water content. We conclude that
although 1 mo of pacing-induced heart failure results in altered
interstitial function, the attendant pulmonary hypertension and/or
hormonal responses are insufficient to induce medial hypertrophy or
other remodeling of the extra-alveolar microvasculature.
interstitial fluid pressure; interstitial matrix; morphometry; pulmonary venous hypertension</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1999.87.5.1823</identifier><identifier>PMID: 10562627</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Anatomy & physiology ; Animals ; Biological and medical sciences ; Blood Vessels - pathology ; Cardiac Pacing, Artificial ; Cardiology. Vascular system ; Collagen - metabolism ; Dogs ; Extracellular Space - metabolism ; Extravascular Lung Water - metabolism ; Glycosaminoglycans - metabolism ; Heart ; Heart failure ; Heart Failure - pathology ; Heart failure, cardiogenic pulmonary edema, cardiac enlargement ; In Vitro Techniques ; Lung - pathology ; Lungs ; Medical sciences ; Microcirculation - pathology ; Microcirculation - physiopathology ; Models, Biological ; Pulmonary Alveoli - pathology ; Pulmonary Alveoli - physiology ; Pulmonary Circulation - physiology ; Space life sciences ; Vascular Resistance - physiology</subject><ispartof>Journal of applied physiology (1985), 1999-11, Vol.87 (5), p.1823-1830</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Physiological Society Nov 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-710d9736804c8f9f9b248493d28bb32089d7cbe875a479153ca6b555fc77bcc3</citedby><cites>FETCH-LOGICAL-c437t-710d9736804c8f9f9b248493d28bb32089d7cbe875a479153ca6b555fc77bcc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1214117$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10562627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Townsley, Mary I</creatorcontrib><creatorcontrib>Snell, Kenneth S</creatorcontrib><creatorcontrib>Ivey, Claire L</creatorcontrib><creatorcontrib>Culberson, Donald E</creatorcontrib><creatorcontrib>Liu, Da Chang</creatorcontrib><creatorcontrib>Reed, Rolf K</creatorcontrib><creatorcontrib>Mathieu-Costello, Odile</creatorcontrib><title>Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>Departments of 1 Physiology and
2 Pathology, University of South
Alabama, Mobile, Alabama 36688;
3 Department of Physiology,
University of Bergen, Bergen, Norway; and
4 Department of Medicine,
University of California, San Diego, La Jolla, California 92103
We previously showed that pacing-induced heart
failure in dogs results in an enhancement of pulmonary vascular
reactivity. In the present study we hypothesized that enhanced matrix
deposition and structural remodeling of lung resistance
microvessels would underlie these functional changes. Using
biochemical measures, we found no difference in the normalized lung
content of hyaluronan, uronic acid, and collagen between control dogs
and dogs paced for 1 mo, although lung dry weight and noncollagen
protein content increased significantly in the paced group
( P < 0.05). From separate Formalin-fixed lung lobes, 5-µm frozen sections were prepared and
stained with Masson's trichrome, and vascular structure was evaluated
using standard morphometric techniques. When perivascular fluid cuffs
were excluded from the measure of wall thickness, collagen and media
volume fractions in any size range did not differ between paced and
control groups. Similarly, in the paced group, medial thickness in
<400-µm arterial or venular microvessels did not vary significantly
from that in the controls. In contrast, the relationship of
interstitial fluid pressure to lung water was significantly shifted to
the right in the paced group, such that normal tissue pressures were
observed, despite the increased water content. We conclude that
although 1 mo of pacing-induced heart failure results in altered
interstitial function, the attendant pulmonary hypertension and/or
hormonal responses are insufficient to induce medial hypertrophy or
other remodeling of the extra-alveolar microvasculature.
interstitial fluid pressure; interstitial matrix; morphometry; pulmonary venous hypertension</description><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - pathology</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiology. Vascular system</subject><subject>Collagen - metabolism</subject><subject>Dogs</subject><subject>Extracellular Space - metabolism</subject><subject>Extravascular Lung Water - metabolism</subject><subject>Glycosaminoglycans - metabolism</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Heart Failure - pathology</subject><subject>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</subject><subject>In Vitro Techniques</subject><subject>Lung - pathology</subject><subject>Lungs</subject><subject>Medical sciences</subject><subject>Microcirculation - pathology</subject><subject>Microcirculation - physiopathology</subject><subject>Models, Biological</subject><subject>Pulmonary Alveoli - pathology</subject><subject>Pulmonary Alveoli - physiology</subject><subject>Pulmonary Circulation - physiology</subject><subject>Space life sciences</subject><subject>Vascular Resistance - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF2L1DAUhoMo7rj6D0SCiHjTmqRJk1zK4qqwIMjchzQ9ncmQaWuSrs6_N3UGv8Crc5HnfU_Og9BzSmpKBXt7sPMcaqq1rpWsRU0Vax6gTXliFW0JfYg2SgpSSaHkFXqS0oEQyrmgj9EVJaJlLZMbZL_Aceoh-HGHpwGHpUw_Zogp--yXI-6WjMcp4wjJp2xHB_geUoKQCoedHf0IeLauFFR-7BcHPd6DjRkP1oclwlP0aLAhwbPLvEbb2_fbm4_V3ecPn27e3VWONzJXkpJey6ZVhDs16EF3jCuum56prmsYUbqXroNykuVSU9E423ZCiMFJ2TnXXKPX59o5Tl8XSNkcfXIQgh1hWpJpNVMtFbqAL_8BD9MSx_I1wxgrRNuqAvEz5OKUUoTBzNEfbTwZSsyq3_zUb1b9RkkjzKq_xF5cupfuCP0fobPvAry6ADY5G4ZYhPr0m2OUU7pib87Y3u_233wEM-9PyU9h2p3WzX-t5P9Hb5cQtvA9r5lfETP3Q_MDTMSwig</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Townsley, Mary I</creator><creator>Snell, Kenneth S</creator><creator>Ivey, Claire L</creator><creator>Culberson, Donald E</creator><creator>Liu, Da Chang</creator><creator>Reed, Rolf K</creator><creator>Mathieu-Costello, Odile</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure</title><author>Townsley, Mary I ; Snell, Kenneth S ; Ivey, Claire L ; Culberson, Donald E ; Liu, Da Chang ; Reed, Rolf K ; Mathieu-Costello, Odile</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-710d9736804c8f9f9b248493d28bb32089d7cbe875a479153ca6b555fc77bcc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - pathology</topic><topic>Cardiac Pacing, Artificial</topic><topic>Cardiology. Vascular system</topic><topic>Collagen - metabolism</topic><topic>Dogs</topic><topic>Extracellular Space - metabolism</topic><topic>Extravascular Lung Water - metabolism</topic><topic>Glycosaminoglycans - metabolism</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Heart Failure - pathology</topic><topic>Heart failure, cardiogenic pulmonary edema, cardiac enlargement</topic><topic>In Vitro Techniques</topic><topic>Lung - pathology</topic><topic>Lungs</topic><topic>Medical sciences</topic><topic>Microcirculation - pathology</topic><topic>Microcirculation - physiopathology</topic><topic>Models, Biological</topic><topic>Pulmonary Alveoli - pathology</topic><topic>Pulmonary Alveoli - physiology</topic><topic>Pulmonary Circulation - physiology</topic><topic>Space life sciences</topic><topic>Vascular Resistance - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Townsley, Mary I</creatorcontrib><creatorcontrib>Snell, Kenneth S</creatorcontrib><creatorcontrib>Ivey, Claire L</creatorcontrib><creatorcontrib>Culberson, Donald E</creatorcontrib><creatorcontrib>Liu, Da Chang</creatorcontrib><creatorcontrib>Reed, Rolf K</creatorcontrib><creatorcontrib>Mathieu-Costello, Odile</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Townsley, Mary I</au><au>Snell, Kenneth S</au><au>Ivey, Claire L</au><au>Culberson, Donald E</au><au>Liu, Da Chang</au><au>Reed, Rolf K</au><au>Mathieu-Costello, Odile</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>87</volume><issue>5</issue><spage>1823</spage><epage>1830</epage><pages>1823-1830</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>Departments of 1 Physiology and
2 Pathology, University of South
Alabama, Mobile, Alabama 36688;
3 Department of Physiology,
University of Bergen, Bergen, Norway; and
4 Department of Medicine,
University of California, San Diego, La Jolla, California 92103
We previously showed that pacing-induced heart
failure in dogs results in an enhancement of pulmonary vascular
reactivity. In the present study we hypothesized that enhanced matrix
deposition and structural remodeling of lung resistance
microvessels would underlie these functional changes. Using
biochemical measures, we found no difference in the normalized lung
content of hyaluronan, uronic acid, and collagen between control dogs
and dogs paced for 1 mo, although lung dry weight and noncollagen
protein content increased significantly in the paced group
( P < 0.05). From separate Formalin-fixed lung lobes, 5-µm frozen sections were prepared and
stained with Masson's trichrome, and vascular structure was evaluated
using standard morphometric techniques. When perivascular fluid cuffs
were excluded from the measure of wall thickness, collagen and media
volume fractions in any size range did not differ between paced and
control groups. Similarly, in the paced group, medial thickness in
<400-µm arterial or venular microvessels did not vary significantly
from that in the controls. In contrast, the relationship of
interstitial fluid pressure to lung water was significantly shifted to
the right in the paced group, such that normal tissue pressures were
observed, despite the increased water content. We conclude that
although 1 mo of pacing-induced heart failure results in altered
interstitial function, the attendant pulmonary hypertension and/or
hormonal responses are insufficient to induce medial hypertrophy or
other remodeling of the extra-alveolar microvasculature.
interstitial fluid pressure; interstitial matrix; morphometry; pulmonary venous hypertension</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>10562627</pmid><doi>10.1152/jappl.1999.87.5.1823</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 1999-11, Vol.87 (5), p.1823-1830 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_10562627 |
| source | MEDLINE; American Physiological Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Anatomy & physiology Animals Biological and medical sciences Blood Vessels - pathology Cardiac Pacing, Artificial Cardiology. Vascular system Collagen - metabolism Dogs Extracellular Space - metabolism Extravascular Lung Water - metabolism Glycosaminoglycans - metabolism Heart Heart failure Heart Failure - pathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement In Vitro Techniques Lung - pathology Lungs Medical sciences Microcirculation - pathology Microcirculation - physiopathology Models, Biological Pulmonary Alveoli - pathology Pulmonary Alveoli - physiology Pulmonary Circulation - physiology Space life sciences Vascular Resistance - physiology |
| title | Remodeling of lung interstitium but not resistance vessels in canine pacing-induced heart failure |
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