Human δ-opioid receptor gene and susceptibility to heroin and alcohol dependence
In the present study, we tested the hypothesis that addictive behavior may be influenced by genetic variation in the human δ‐opioid receptor gene. We investigated the contribution of a silent T to C change in the coding region to the development of heroin and alcohol dependence using large case‐cont...
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| Veröffentlicht in: | American journal of medical genetics 1999-10, Vol.88 (5), p.462-464 |
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| container_title | American journal of medical genetics |
| container_volume | 88 |
| creator | Franke, Petra Nöthen, Markus M. Wang, Tao Neidt, Helge Knapp, Michael Lichtermann, Dirk Weiffenbach, Olaf Mayer, Peter Höllt, Volker Propping, Peter Maier, Wolfgang |
| description | In the present study, we tested the hypothesis that addictive behavior may be influenced by genetic variation in the human δ‐opioid receptor gene. We investigated the contribution of a silent T to C change in the coding region to the development of heroin and alcohol dependence using large case‐control and family‐based association samples. Presence of the C allele was previously reported to significantly increase the risk for heroin dependence. In the present study, however, we did not find statistically significant differences between patients and controls nor did we find preferential transmission of the C allele from parents to affected offspring. Our results, therefore, do not support an association between genetic variation of the δ‐opioid receptor and addictive behavior in man. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:462–464, 1999. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-8628(19991015)88:5<462::AID-AJMG4>3.0.CO;2-S |
| format | Article |
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We investigated the contribution of a silent T to C change in the coding region to the development of heroin and alcohol dependence using large case‐control and family‐based association samples. Presence of the C allele was previously reported to significantly increase the risk for heroin dependence. In the present study, however, we did not find statistically significant differences between patients and controls nor did we find preferential transmission of the C allele from parents to affected offspring. Our results, therefore, do not support an association between genetic variation of the δ‐opioid receptor and addictive behavior in man. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:462–464, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/(SICI)1096-8628(19991015)88:5<462::AID-AJMG4>3.0.CO;2-S</identifier><identifier>PMID: 10490698</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>addiction ; Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; alcoholism ; Alcoholism - genetics ; Alleles ; Biological and medical sciences ; candidate gene ; Case-Control Studies ; case-control study ; Drug addiction ; Drug addictions ; family-based association study ; Female ; Genetic Predisposition to Disease ; Genotype ; heroin dependence ; Heroin Dependence - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Parents ; Polymorphism, Genetic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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J. Med. Genet</addtitle><description>In the present study, we tested the hypothesis that addictive behavior may be influenced by genetic variation in the human δ‐opioid receptor gene. We investigated the contribution of a silent T to C change in the coding region to the development of heroin and alcohol dependence using large case‐control and family‐based association samples. Presence of the C allele was previously reported to significantly increase the risk for heroin dependence. In the present study, however, we did not find statistically significant differences between patients and controls nor did we find preferential transmission of the C allele from parents to affected offspring. Our results, therefore, do not support an association between genetic variation of the δ‐opioid receptor and addictive behavior in man. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:462–464, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>addiction</subject><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>alcoholism</subject><subject>Alcoholism - genetics</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>candidate gene</subject><subject>Case-Control Studies</subject><subject>case-control study</subject><subject>Drug addiction</subject><subject>Drug addictions</subject><subject>family-based association study</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>heroin dependence</subject><subject>Heroin Dependence - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Parents</subject><subject>Polymorphism, Genetic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Receptors, Opioid, delta - genetics</subject><subject>Toxicology</subject><subject>δ-opioid receptor gene</subject><issn>0148-7299</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkd1O20AQhVeoCFLoKyBf9AIuNuyf7d0UtUrdElIBEQr9uRutveOy4NiWnajNe_EcPBM2Adqrkc6cOZqZj5BPnA05Y-L4cD5NpkecmYjqSOhDbozhjIdHWo_CExWJ0Wg8_ULH3y4m6qMcsmEy-yDofIsMXmfekAHjStNYGLNL3rbtLWO8E8QO2eVMGRYZPSBXZ6uFLYOHe1rVvvIuaDDDelk1wW8sMbClC9pV20s-9YVfroNlFdxgU_nyqWmLrLqpisBhjaXDMsN9sp3bosV3z3WPfD_9ep2c0fPZZJqMz6mXYaioSePU6FzEWiBLZcqRo3SYqSi3HJ3LuyO1jVHlwlgpWKaVQ5E7pzKbu8jKPXKwya1X6QId1I1f2GYNL7d1hvfPBttmtsgbW2a-_eczmgsddbZfG9sfX-D6vxjoSUAPAvqnQv9UeAEBWkMI3Y7QcYAnDiCBQTKDbmYjdNF0E-3bJf59jbbNHUSxjEP4eTmB8PLzj4tTcQVz-QhqzpH_</recordid><startdate>19991015</startdate><enddate>19991015</enddate><creator>Franke, Petra</creator><creator>Nöthen, Markus M.</creator><creator>Wang, Tao</creator><creator>Neidt, Helge</creator><creator>Knapp, Michael</creator><creator>Lichtermann, Dirk</creator><creator>Weiffenbach, Olaf</creator><creator>Mayer, Peter</creator><creator>Höllt, Volker</creator><creator>Propping, Peter</creator><creator>Maier, Wolfgang</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19991015</creationdate><title>Human δ-opioid receptor gene and susceptibility to heroin and alcohol dependence</title><author>Franke, Petra ; Nöthen, Markus M. ; Wang, Tao ; Neidt, Helge ; Knapp, Michael ; Lichtermann, Dirk ; Weiffenbach, Olaf ; Mayer, Peter ; Höllt, Volker ; Propping, Peter ; Maier, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3554-9b7b98f2782e0b3b1e1e3dec46fa1eddf4628a7e4f29a320c84de2fdd4cafd6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>addiction</topic><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>alcoholism</topic><topic>Alcoholism - genetics</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>candidate gene</topic><topic>Case-Control Studies</topic><topic>case-control study</topic><topic>Drug addiction</topic><topic>Drug addictions</topic><topic>family-based association study</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>heroin dependence</topic><topic>Heroin Dependence - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Parents</topic><topic>Polymorphism, Genetic</topic><topic>Psychology. 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| language | eng |
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| subjects | addiction Addictive behaviors Adult Adult and adolescent clinical studies alcoholism Alcoholism - genetics Alleles Biological and medical sciences candidate gene Case-Control Studies case-control study Drug addiction Drug addictions family-based association study Female Genetic Predisposition to Disease Genotype heroin dependence Heroin Dependence - genetics Humans Male Medical sciences Middle Aged Parents Polymorphism, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Receptors, Opioid, delta - genetics Toxicology δ-opioid receptor gene |
| title | Human δ-opioid receptor gene and susceptibility to heroin and alcohol dependence |
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