Pharmacokinetic Study of S-1, a Novel Oral Fluorouracil Antitumor Drug

S-1 is a novel oral fluorouracil antitumor drug that combines three pharmacological agents: tegafur (FT), which is a prodrug of 5-fluorouracil (5-FU); 5-chloro-2,4-dihydroxypyridine (CDHP), which inhibits dihydropyrimidine dehydrogenase (DPD) activity; and potassium oxonate (Oxo), which reduces gast...

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Veröffentlicht in:	Clinical cancer research 1999-08, Vol.5 (8), p.2000-2005
Hauptverfasser:	HIRATA, K, HORIKOSHI, N, TAGUCHI, T, SHIRASAKA, T, AIBA, K, OKAZAKI, M, DENNO, R, SASAKI, K, NAKANO, Y, ISHIZUKA, H, YAMADA, Y, UNO, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - blood Antimetabolites, Antineoplastic - pharmacokinetics Antimetabolites, Antineoplastic - urine Antineoplastic agents Biological and medical sciences Breast Neoplasms - blood Breast Neoplasms - drug therapy Breast Neoplasms - urine Chemotherapy Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - urine Drug Combinations Drug Evaluation Female Humans Male Medical sciences Middle Aged Neoplasms - blood Neoplasms - drug therapy Neoplasms - urine Oxonic Acid - adverse effects Oxonic Acid - blood Oxonic Acid - pharmacokinetics Oxonic Acid - urine Pharmacology. Drug treatments Pyridines - adverse effects Pyridines - blood Pyridines - pharmacokinetics Pyridines - urine Stomach Neoplasms - blood Stomach Neoplasms - drug therapy Stomach Neoplasms - urine Tegafur - adverse effects Tegafur - blood Tegafur - pharmacokinetics Tegafur - urine
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