Prostaglandin E2 downregulates interferon-gamma-induced intercellular adhesion molecule-1 expression via EP2 receptors in human gingival fibroblasts

In the present study, the effect of prostaglandin E2 (PGE2) on intercellular adhesion molecule-1 (ICAM-1) expression in interferon-gamma (IFN-gamma)-stimulated human gingival fibroblasts (HGF) was investigated. Addition of PGE2 to HGF inhibited ICAM-1 expression elicited by IFN-gamma. As PGE2 elevat...

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Veröffentlicht in:	Inflammation 1999-10, Vol.23 (5), p.481
Hauptverfasser:	Noguchi, K, Iwasaki, K, Shitashige, M, Murato, S, Ishikawa, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cells, Cultured Dinoprostone - pharmacology Down-Regulation - drug effects Drug Antagonism Fibroblasts - metabolism Gingiva Humans Intercellular Adhesion Molecule-1 - biosynthesis Interferon-gamma - pharmacology Oxytocics - pharmacology Receptors, Prostaglandin E - metabolism
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