Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazephine AMPA antagonists
A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1999-07, Vol.9 (14), p.1953 |
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| container_issue | 14 |
| container_start_page | 1953 |
| container_title | Bioorganic & medicinal chemistry letters |
| container_volume | 9 |
| creator | Anderson, B A Harn, N K Hansen, M M Harkness, A R Lodge, D Leander, J D |
| description | A novel series of 3-aryl-5H-2,3-benzodiazepines with N-3 aromatic substituents has been synthesized. Good in vivo anticonvulsant activity of the new compounds has been demonstrated employing the maximal electroshock seizure test in mice. Evaluation of a subset of the compounds in the cortical wedge assay confirmed the new structures to be AMPA antagonists. |
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1999-07, Vol.9 (14), p.1953 |
| issn | 0960-894X |
| language | eng |
| recordid | cdi_pubmed_primary_10450961 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - antagonists & inhibitors Animals Anticonvulsants - chemical synthesis Anticonvulsants - pharmacology Benzodiazepines - chemical synthesis Benzodiazepines - chemistry Benzodiazepines - pharmacology Dose-Response Relationship, Drug Electroshock Mice Seizures - drug therapy Structure-Activity Relationship |
| title | Synthesis and anticonvulsant activity of 3-aryl-5H-2,3-benzodiazephine AMPA antagonists |
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