Neurotrophic Activity of Pituitary Adenylate Cyclase-Activating Polypeptide on Rat Cerebellar Cortex during Development

High concentrations of pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are present in the external granule cell layer of the rat cerebellum during postnatal development. In vitro studies have shown that PACAP promotes cell survival and neurite outgrowth on immature cerebellar gr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-08, Vol.96 (16), p.9415-9420
Hauptverfasser:	Vaudry, David, Gonzalez, Bruno J., Basille, Magali, Fournier, Alain, Vaudry, Hubert
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Apoptosis Biological Sciences Brain Cell Division - drug effects Cell growth Cell Survival - drug effects Cells Cells, Cultured Cerebellar cortex Cerebellar Cortex - cytology Cerebellar Cortex - drug effects Cerebellar Cortex - growth & development Cerebellum Cerebellum - cytology Cerebellum - drug effects Cerebellum - growth & development Cultured cells DNA - biosynthesis Dose-Response Relationship, Drug Kinetics Neurites - drug effects Neurites - physiology Neurons Neurons - cytology Neurons - drug effects Neurons - physiology Neuropeptides - pharmacology Neuroprotective Agents - pharmacology Neuroscience Peptides Pituitary adenylate cyclase activating peptide receptors Pituitary Adenylate Cyclase-Activating Polypeptide Pituitary gland Purkinje cells Rats Rats, Wistar Rodents Thymidine - metabolism
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