Possible Involvement of Atypical Protein Kinase C (PKC) in Glucose-Sensitive Expression of the Human Insulin Gene: DNA-Binding Activity and Transcriptional Activity of Pancreatic and Duodenal Homeobox Gene-1 (PDX-1) Are Enhanced via Calphostin C-Sensitive but Phorbol 12-Myristate 13-Acetate (PMA) and Gö 6976-Insensitive Pathway

Pancreatic and duodenal homeobox gene-1(PDX-1) is a transcription factor which regulates the insulin gene expression. In this study, we tried to elucidate the role of PDX-1 in the glucose-induced transcriptional activation of the human insulin gene promoter in MINE cells. Electrophoretic mobility sh...

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Veröffentlicht in:	ENDOCRINE JOURNAL 1999, Vol.46(1), pp.43-58
Hauptverfasser:	FURUKAWA, NOBORU, SHIROTANI, TETSUYA, ARAKI, EIICHI, KANEKO, KENGO, TODAKA, MIKIO, MATSUMOTO, KAZUYA, TSURUZOE, KAKU, MOTOSHIMA, HIROYUKI, YOSHIZATO, KAZUAKI, KISHIKAWA, HIDEKI, SHICHIRI, MOTOAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atypical protein kinase C Carbazoles - pharmacology Cell Line DNA - metabolism Enzyme Inhibitors - pharmacology Gene Expression - drug effects Glucose - pharmacology Homeodomain Proteins - genetics Humans Indoles - pharmacology Insulin - genetics Insulin gene expression Islets of Langerhans Mice MIN6 cell Naphthalenes - pharmacology Pancreatic and duodenal homeobox gene-1 (PDX-1) Phosphoric Monoester Hydrolases - pharmacology Phosphorylation Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Tetradecanoylphorbol Acetate - pharmacology Trans-Activators - genetics Transcription, Genetic Transfection
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