Cytotoxicity induced by the combination of valproic acid and tumor necrosis factor-α: Implication for valproic acid-associated hepatotoxicity syndrome

A previous study showed that valproic acid (VPA) and tumor necrosis factor-α (TNF-α) exhibit synergistic toxicity (lethality) in Sprague–Dawley and Wistar rats. The present study investigated a possible mechanism for this synergy using an in vitro system. Incubation of human U937 cells with 1 mM VPA...

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Veröffentlicht in:	Biochemical pharmacology 1999-08, Vol.58 (3), p.455-459
Hauptverfasser:	Yao, Cai-ping, Mather, Gary G, Stephens, Jeffrey R, Levy, René H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - toxicity Biological and medical sciences Cell Survival - drug effects cytotoxicity Cytotoxins - toxicity Drug Synergism Drug toxicity and drugs side effects treatment Enzyme Inhibitors - toxicity Humans Liver - drug effects Liver - enzymology Medical sciences Pharmacology. Drug treatments PKC Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Rats Rats, Sprague-Dawley Rats, Wistar TNF-α Toxicity: digestive system Tumor Necrosis Factor-alpha - toxicity U937 Cells Valproic Acid - toxicity VPA VPA-associated hepatotoxicity syndrome
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