Gastroduodenal Mucosal Vitamin-C Levels in Helicobacter pylori Infection
Background: Vitamin C is an important endogenous antioxidant, and epidemiologic evidence suggests that it may protect against the development of gastric cancer. We therefore determined mucosal vitamin-C levels in the stomach and duodenum of subjects with and without Helicobacter pylori infection. Me...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1999, Vol.34 (4), p.361-366 |
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| creator | PHULL, P. S PRICE, A. B WHITE, K. L. M SCHORAH, C. J JACYNA, M. R |
| description | Background: Vitamin C is an important endogenous antioxidant, and epidemiologic evidence suggests that it may protect against the development of gastric cancer. We therefore determined mucosal vitamin-C levels in the stomach and duodenum of subjects with and without Helicobacter pylori infection. Methods: The patients were 30 subjects undergoing routine gastroscopy for investigation of dyspepsia. High-performance liquid chromatography with electrochemical detection was used to determine mucosal ascorbic acid and total vitamin-C levels. Results: In H. pylori-negative subjects with normal gastroduodenal histology the antrum contained significantly higher levels of ascorbic acid and total vitamin C than the corpus or duodenum (P < 0.05). No significant changes were seen in gastric mucosal ascorbic acid or total vitamin-C levels in the presence of H. pylori infection and related inflammation. The presence of gastric atrophy did not affect mucosal ascorbic acid or total vitamin C levels. Duodenal ascorbic acid and total vitamin-C levels did not change significantly in the presence of gastric H. pylori or duodenal inflammation. Conclusions: Although high levels of vitamin C are present in the gastroduodenal mucosa, these are not altered in the presence of H. pylori infection and inflammation. These observations suggest that the mucosal antioxidant potential of vitamin C is not impaired by H. pylori infection. |
| doi_str_mv | 10.1080/003655299750026362 |
| format | Article |
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S ; PRICE, A. B ; WHITE, K. L. M ; SCHORAH, C. J ; JACYNA, M. R</creator><creatorcontrib>PHULL, P. S ; PRICE, A. B ; WHITE, K. L. M ; SCHORAH, C. J ; JACYNA, M. R</creatorcontrib><description>Background: Vitamin C is an important endogenous antioxidant, and epidemiologic evidence suggests that it may protect against the development of gastric cancer. We therefore determined mucosal vitamin-C levels in the stomach and duodenum of subjects with and without Helicobacter pylori infection. Methods: The patients were 30 subjects undergoing routine gastroscopy for investigation of dyspepsia. High-performance liquid chromatography with electrochemical detection was used to determine mucosal ascorbic acid and total vitamin-C levels. Results: In H. pylori-negative subjects with normal gastroduodenal histology the antrum contained significantly higher levels of ascorbic acid and total vitamin C than the corpus or duodenum (P < 0.05). No significant changes were seen in gastric mucosal ascorbic acid or total vitamin-C levels in the presence of H. pylori infection and related inflammation. The presence of gastric atrophy did not affect mucosal ascorbic acid or total vitamin C levels. Duodenal ascorbic acid and total vitamin-C levels did not change significantly in the presence of gastric H. pylori or duodenal inflammation. Conclusions: Although high levels of vitamin C are present in the gastroduodenal mucosa, these are not altered in the presence of H. pylori infection and inflammation. These observations suggest that the mucosal antioxidant potential of vitamin C is not impaired by H. pylori infection.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/003655299750026362</identifier><identifier>PMID: 10365895</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Antioxidants - metabolism ; Ascorbic Acid - metabolism ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Biopsy ; Case-Control Studies ; Chromatography, High Pressure Liquid ; Duodenitis - metabolism ; Duodenitis - microbiology ; Duodenum - chemistry ; Female ; Gastric Mucosa - chemistry ; Gastritis - metabolism ; Gastritis - microbiology ; Gastroscopy ; Helicobacter Infections - metabolism ; Helicobacter pylori ; Human bacterial diseases ; Humans ; Infectious diseases ; Intestinal Mucosa - chemistry ; Male ; Medical sciences ; Middle Aged</subject><ispartof>Scandinavian journal of gastroenterology, 1999, Vol.34 (4), p.361-366</ispartof><rights>1999 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-8234d0404c5bb43b302850c95d995a1e483b7bdeb2fe386d316973b82bca2da03</citedby><cites>FETCH-LOGICAL-c435t-8234d0404c5bb43b302850c95d995a1e483b7bdeb2fe386d316973b82bca2da03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/003655299750026362$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/003655299750026362$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4009,27902,27903,27904,59624,59730,60413,60519,61198,61233,61379,61414</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1789820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10365895$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PHULL, P. S</creatorcontrib><creatorcontrib>PRICE, A. B</creatorcontrib><creatorcontrib>WHITE, K. L. M</creatorcontrib><creatorcontrib>SCHORAH, C. J</creatorcontrib><creatorcontrib>JACYNA, M. R</creatorcontrib><title>Gastroduodenal Mucosal Vitamin-C Levels in Helicobacter pylori Infection</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: Vitamin C is an important endogenous antioxidant, and epidemiologic evidence suggests that it may protect against the development of gastric cancer. We therefore determined mucosal vitamin-C levels in the stomach and duodenum of subjects with and without Helicobacter pylori infection. Methods: The patients were 30 subjects undergoing routine gastroscopy for investigation of dyspepsia. High-performance liquid chromatography with electrochemical detection was used to determine mucosal ascorbic acid and total vitamin-C levels. Results: In H. pylori-negative subjects with normal gastroduodenal histology the antrum contained significantly higher levels of ascorbic acid and total vitamin C than the corpus or duodenum (P < 0.05). No significant changes were seen in gastric mucosal ascorbic acid or total vitamin-C levels in the presence of H. pylori infection and related inflammation. The presence of gastric atrophy did not affect mucosal ascorbic acid or total vitamin C levels. Duodenal ascorbic acid and total vitamin-C levels did not change significantly in the presence of gastric H. pylori or duodenal inflammation. Conclusions: Although high levels of vitamin C are present in the gastroduodenal mucosa, these are not altered in the presence of H. pylori infection and inflammation. These observations suggest that the mucosal antioxidant potential of vitamin C is not impaired by H. pylori infection.</description><subject>Adult</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic Acid - metabolism</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Duodenitis - metabolism</subject><subject>Duodenitis - microbiology</subject><subject>Duodenum - chemistry</subject><subject>Female</subject><subject>Gastric Mucosa - chemistry</subject><subject>Gastritis - metabolism</subject><subject>Gastritis - microbiology</subject><subject>Gastroscopy</subject><subject>Helicobacter Infections - metabolism</subject><subject>Helicobacter pylori</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Intestinal Mucosa - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVpabZp_0APxYeSm5uRZNkSJIewtNnAllzSXo0-xkRBtraSnZB_H5vd0oZATnN5npeZdwj5TOEbBQmnALwWginVCABW85q9ISsqgJVNA_ItWS1AORP0iHzI-Q4ARFOp9-SILqZUYkU2lzqPKbopOhx0KH5ONuZ5_vaj7v1Qrost3mPIhR-KDQZvo9F2xFTsHkNMvrgaOrSjj8NH8q7TIeOnwzwmv358v1lvyu315dX6YlvaiouxlIxXDiqorDCm4oYDkwKsEk4poSlWkpvGODSsQy5rx2mtGm4kM1Yzp4Efk5N97i7FPxPmse19thiCHjBOua2VpDCfP4NsD9oUc07Ytbvke50eWwrt0l_7sr9Z-nJIn0yP7j9lX9gMfD0AOlsduqQH6_M_rpFKsmXL8z3mhy6mXj_EFFw76qW0vw5_dY-zZ_4t6jDeWp2wvYtTmj-VXzvjCVznnIw</recordid><startdate>1999</startdate><enddate>1999</enddate><creator>PHULL, P. S</creator><creator>PRICE, A. B</creator><creator>WHITE, K. L. M</creator><creator>SCHORAH, C. J</creator><creator>JACYNA, M. R</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1999</creationdate><title>Gastroduodenal Mucosal Vitamin-C Levels in Helicobacter pylori Infection</title><author>PHULL, P. S ; PRICE, A. B ; WHITE, K. L. M ; SCHORAH, C. J ; JACYNA, M. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-8234d0404c5bb43b302850c95d995a1e483b7bdeb2fe386d316973b82bca2da03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Antioxidants - metabolism</topic><topic>Ascorbic Acid - metabolism</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Duodenitis - metabolism</topic><topic>Duodenitis - microbiology</topic><topic>Duodenum - chemistry</topic><topic>Female</topic><topic>Gastric Mucosa - chemistry</topic><topic>Gastritis - metabolism</topic><topic>Gastritis - microbiology</topic><topic>Gastroscopy</topic><topic>Helicobacter Infections - metabolism</topic><topic>Helicobacter pylori</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Intestinal Mucosa - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PHULL, P. S</creatorcontrib><creatorcontrib>PRICE, A. B</creatorcontrib><creatorcontrib>WHITE, K. L. M</creatorcontrib><creatorcontrib>SCHORAH, C. J</creatorcontrib><creatorcontrib>JACYNA, M. R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PHULL, P. S</au><au>PRICE, A. B</au><au>WHITE, K. L. M</au><au>SCHORAH, C. J</au><au>JACYNA, M. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroduodenal Mucosal Vitamin-C Levels in Helicobacter pylori Infection</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1999</date><risdate>1999</risdate><volume>34</volume><issue>4</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Background: Vitamin C is an important endogenous antioxidant, and epidemiologic evidence suggests that it may protect against the development of gastric cancer. We therefore determined mucosal vitamin-C levels in the stomach and duodenum of subjects with and without Helicobacter pylori infection. Methods: The patients were 30 subjects undergoing routine gastroscopy for investigation of dyspepsia. High-performance liquid chromatography with electrochemical detection was used to determine mucosal ascorbic acid and total vitamin-C levels. Results: In H. pylori-negative subjects with normal gastroduodenal histology the antrum contained significantly higher levels of ascorbic acid and total vitamin C than the corpus or duodenum (P < 0.05). No significant changes were seen in gastric mucosal ascorbic acid or total vitamin-C levels in the presence of H. pylori infection and related inflammation. The presence of gastric atrophy did not affect mucosal ascorbic acid or total vitamin C levels. Duodenal ascorbic acid and total vitamin-C levels did not change significantly in the presence of gastric H. pylori or duodenal inflammation. Conclusions: Although high levels of vitamin C are present in the gastroduodenal mucosa, these are not altered in the presence of H. pylori infection and inflammation. These observations suggest that the mucosal antioxidant potential of vitamin C is not impaired by H. pylori infection.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>10365895</pmid><doi>10.1080/003655299750026362</doi><tpages>6</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1999, Vol.34 (4), p.361-366 |
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| subjects | Adult Antioxidants - metabolism Ascorbic Acid - metabolism Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biopsy Case-Control Studies Chromatography, High Pressure Liquid Duodenitis - metabolism Duodenitis - microbiology Duodenum - chemistry Female Gastric Mucosa - chemistry Gastritis - metabolism Gastritis - microbiology Gastroscopy Helicobacter Infections - metabolism Helicobacter pylori Human bacterial diseases Humans Infectious diseases Intestinal Mucosa - chemistry Male Medical sciences Middle Aged |
| title | Gastroduodenal Mucosal Vitamin-C Levels in Helicobacter pylori Infection |
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