Relaxation of Contracted Rabbit Tracheal and Human Bronchial Smooth Muscle by Y-27632 through Inhibition of Ca2+ Sensitization

The mechanism of Ca2+ sensitization of contraction has not been elucidated in airway smooth muscle (SM). To determine the role of a small G protein, rhoA p21, and its target protein, rho-associated coiled coil-forming protein kinase (ROCK), in receptor-coupled Ca2+ sensitization of airway SM, we stu...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 1999-06, Vol.20 (6), p.1190
Hauptverfasser:	Yoshii, Akihiro, Iizuka, Kunihiko, Dobashi, Kunio, Horie, Takeo, Harada, Takashi, Nakazawa, Tsugio, Mori, Masatomo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology Amides - pharmacology Animals Bronchi - metabolism Calcium - antagonists & inhibitors Carbachol - pharmacology Cholinergic Agents - pharmacology Detergents - pharmacology Dose-Response Relationship, Drug Endothelin-1 - pharmacology GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Intracellular Signaling Peptides and Proteins Muscle Contraction Muscle, Smooth - metabolism Myosin-Light-Chain Kinase - metabolism Octoxynol - pharmacology Oxazoles - pharmacology Phosphodiesterase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - metabolism Pyridines - pharmacology Rabbits rho-Associated Kinases Signal Transduction Trachea - metabolism Type C Phospholipases - pharmacology
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