Several Different Ion Channel Modulators Abrogate Contact Hypersensitivity in Mice

A major obstacle in transdermal delivery of drugs is the development of adverse skin sensitization reactions. We tested the concept that ion channel modulators as a class of agents suppress contact hypersensitivity in a mouse model. Mice were sensitized to several contact sensitizing chemicals inclu...

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Veröffentlicht in:	Skin pharmacology and applied skin physiology 1999-01, Vol.12 (1-2), p.12-17
Hauptverfasser:	Wille, John J., Kydonieus, Agis, Kalish, Richard S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - pharmacology Animals Biological and medical sciences Calcium Channel Blockers - pharmacology Dermatitis, Contact - prevention & control Dinitrochlorobenzene - adverse effects Diuretics - pharmacology Drug Interactions Drug toxicity and drugs side effects treatment Ear, External - physiology Edema - chemically induced Female Medical sciences Mice Mice, Inbred CBA Nadolol - adverse effects Original Research Article Pharmacology. Drug treatments Toxicity: skin, dermoskeleton
Online-Zugang:	Volltext
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