Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors

Arachidonic acid (AA) metabolizing enzymes are emerging as significant mediators of growth stimulation for epithelial cells. The relative contribution of the various family members of AA metabolizing enzymes to epithelial cancer cell growth is not known. To study this question, we first analyzed a s...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-05, Vol.59 (9), p.2223-2228
Hauptverfasser:	HONG, S. H, AVIS, I, VOS, M. D, MARTINEZ, A, TRESTON, A. M, MULSHINE, J. L
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase-Activating Proteins Arachidonate 12-Lipoxygenase - metabolism Arachidonate 5-Lipoxygenase - metabolism Arachidonic Acid - metabolism Biological and medical sciences Breast Neoplasms - enzymology Breast Neoplasms - pathology Carcinoma - enzymology Carcinoma - pathology Carrier Proteins - antagonists & inhibitors Carrier Proteins - metabolism Cell Division - drug effects Cell metabolism, cell oxidation Cell physiology Colonic Neoplasms - enzymology Colonic Neoplasms - pathology Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Drug Screening Assays, Antitumor Enzyme Induction - drug effects Epithelial Cells - drug effects Epithelial Cells - enzymology Female Fundamental and applied biological sciences. Psychology Growth Inhibitors - pharmacology Humans Isoenzymes - metabolism Lipoxygenase Inhibitors - pharmacology Lung Neoplasms - enzymology Lung Neoplasms - pathology Male Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Molecular and cellular biology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Prostaglandin-Endoperoxide Synthases - metabolism Prostatic Neoplasms - enzymology Prostatic Neoplasms - pathology RNA, Messenger - biosynthesis RNA, Neoplasm - biosynthesis Signal Transduction - drug effects Signal Transduction - physiology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - enzymology
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