Prognostic Implication of FLT3 and N-RAS Gene Mutations in Acute Myeloid Leukemia

Internal tandem duplication of the FLT3 gene and point mutations of the N-RAS gene are the most frequent somatic mutations causing aberrant signal-transduction in acute myeloid leukemia (AML). However, their prognostic importance is unclear. In this study, their prognostic significance was analyzed...

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Veröffentlicht in:	Blood 1999-05, Vol.93 (9), p.3074-3080
Hauptverfasser:	Kiyoi, Hitoshi, Naoe, Tomoki, Nakano, Yasuyuki, Yokota, Shohei, Minami, Saburo, Miyawaki, Shuichi, Asou, Norio, Kuriyama, Kazutaka, Jinnai, Itsuro, Shimazaki, Chihiro, Akiyama, Hideki, Saito, Kenji, Oh, Hakumei, Motoji, Toshiko, Omoto, Eijiro, Saito, Hidehiko, Ohno, Ryuzo, Ueda, Ryuzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cytarabine - administration & dosage Cytarabine - analogs & derivatives Disease-Free Survival Female fms-Like Tyrosine Kinase 3 Genes, ras Hematologic and hematopoietic diseases Humans Leukemia, Myeloid - blood Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - mortality Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Male Medical sciences Middle Aged Mutation Prognosis Proto-Oncogene Proteins - genetics Proto-Oncogenes Receptor Protein-Tyrosine Kinases - genetics Remission Induction Survival Rate
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