Inhibition of PC-3 human androgen-independent prostate cancer and its metastases by cytotoxic somatostatin analogue AN-238

We evaluated whether AN-238, the cytotoxic analogue of somatostatin (SST) consisting of the radical 2-pyrrolinodoxorubicin (AN-201) linked covalently to the SST octapeptide carrier RC-121 (D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2), could be used for targeting human primary and metastatic prostate car...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1999-04, Vol.59 (8), p.1947-1953
Hauptverfasser:	PLONOWSKI, A, SCHALLY, A. V, NAGY, A, BAODONG SUN, SZEPESHAZI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - metabolism Animals Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Chemotherapy Doxorubicin - analogs & derivatives Doxorubicin - therapeutic use Gene Expression - drug effects Humans Lymphatic Metastasis - prevention & control Male Medical sciences Mice Mice, Nude Neoplasm Metastasis - prevention & control Neoplasm Transplantation Pharmacology. Drug treatments Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Pyrroles - therapeutic use Receptors, Somatostatin - biosynthesis Somatostatin - analogs & derivatives Transplantation, Heterologous Tumor Cells, Cultured
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