Aldosterone directly induces Na, K-ATPase alpha 1-subunit mRNA in the renal cortex of rat

The change of blood pressure and the induction of Na, K-ATPase alpha 1-subunit mRNA have been investigated in the renal cortex of aldosterone-treated hypertensive rat. The increase of blood pressure by aldosterone-treatment for 25 days was decreased by the treatment of amiloride or spironolactone. T...

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Veröffentlicht in:	Biochemistry and molecular biology international 1999-02, Vol.47 (2), p.251
Hauptverfasser:	Seok, J H, Hong, J H, Jeon, J R, Hur, G M, Sung, J Y, Lee, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldosterone - pharmacology Amiloride - pharmacology Animals Blood Pressure - drug effects Gene Expression Regulation, Enzymologic - drug effects Hypertension - chemically induced Kidney - drug effects Rats Rats, Inbred Strains RNA, Messenger - biosynthesis Sodium Channels - metabolism Sodium-Potassium-Exchanging ATPase - chemistry Sodium-Potassium-Exchanging ATPase - genetics Spironolactone - pharmacology Time Factors
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