Identification of Protein Kinase C Phosphorylation Sites Involved in Phorbol Ester-Induced Desensitization of the Histamine H1 Receptor

The histamine H1 receptor (H1R)-mediated signaling cascade is inhibited by phorbol ester-induced protein kinase C (PKC) activation. Cloning studies of the H1Rs have shown that several potential PKC phosphorylation sites are located in the third intracellular loop of H1R. To elucidate the molecular m...

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Veröffentlicht in:	Molecular pharmacology 1999-04, Vol.55 (4), p.735-742
Hauptverfasser:	Fujimoto, Katsumi, Ohta, Kazumi, Kangawa, Kenji, Kikkawa, Ushio, Ogino, Satoshi, Fukui, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals CHO Cells Cricetinae Humans Molecular Sequence Data Mutation - drug effects Peptide Fragments - metabolism Phosphorylation Protein Kinase C - metabolism Receptors, Histamine H1 - genetics Receptors, Histamine H1 - metabolism Sequence Homology, Amino Acid Serine - metabolism Tetradecanoylphorbol Acetate - pharmacology
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