Distinct roles for Galphai2, Galphai3, and Gbeta gamma in modulation offorskolin- or Gs-mediated cAMP accumulation and calcium mobilization by dopamine D2S receptors

Previous studies have shown that a single G protein-coupled receptor can regulate different effector systems by signaling through multiple subtypes of heterotrimeric G proteins. In LD2S fibroblast cells, the dopamine D2S receptor couples to pertussis toxin (PTX)-sensitive Gi/Go proteins to inhibit f...

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Veröffentlicht in:	The Journal of biological chemistry 1999-04, Vol.274 (14), p.9238
Hauptverfasser:	Ghahremani, M H, Cheng, P, Lembo, P M, Albert, P R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin Adenylyl Cyclase Inhibitors Animals Calcium - metabolism Cells, Cultured Colforsin - metabolism Cyclic AMP - metabolism GTP-Binding Protein alpha Subunits, Gs - physiology GTP-Binding Proteins - physiology Mice Mutagenesis, Site-Directed Pertussis Toxin Receptors, Dopamine D2 - metabolism Transfection Virulence Factors, Bordetella - pharmacology
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