GABA may function tonically via GABA A receptors to inhibit hypotension and bradycardia by l-DOPA microinjected into depressor sites of the nucleus tractus solitarii in anesthetized rats

We have proposed that DOPA is a transmitter of the primary baroreceptor afferents terminating in the rat nucleus tractus solitarii (NTS). GABA is a putative inhibitory neuromodulator for baroreflex inputs in the NTS. GABA may inhibit DOPAergic transmission. Drugs were microinjected into depressor si...

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Veröffentlicht in:	Neuroscience letters 1999-02, Vol.261 (1), p.93-96
Hauptverfasser:	Honjo, Kaneyoshi, Goshima, Yoshio, Miyamae, Takeaki, Misu, Yoshimi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Bicuculline - pharmacology Binding, Competitive - physiology Bradycardia - chemically induced Bradycardia - physiopathology Competitive DOPA antagonist Depressor responses to DOPA Dopamine Agents - pharmacology Dose-Response Relationship, Drug GABA A receptors GABA Antagonists - pharmacology gamma-Aminobutyric Acid - pharmacology Hypotension - chemically induced Hypotension - physiopathology Levodopa - pharmacology Male Microinjection Microinjections Nipecotic Acids - pharmacology Nucleus tractus solitarii Pressor responses to GABA Pressoreceptors - drug effects Pressoreceptors - physiology Proline - analogs & derivatives Rats Rats, Wistar Receptors, GABA-A - physiology Solitary Nucleus - chemistry Solitary Nucleus - drug effects Solitary Nucleus - physiology Tritium
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