MALARIA: New Developments in Treatment and Prevention
Malaria still kills some 0.5-2.5 million people per year in the tropics. Resistance to the cheap, most commonly used antimalarials continues to spread alarmingly and could outpace drug development. The artemisinin derivatives have had an important clinical impact both on the treatment of resistant f...
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| Veröffentlicht in: | Annual review of medicine 1999-01, Vol.50 (1), p.179-192 |
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| container_title | Annual review of medicine |
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| creator | Newton, BM, DPhil, MRCP, Paul White, DSc, MD, FRCP, Nicholas |
| description | Malaria still kills some 0.5-2.5 million people per year in the
tropics. Resistance to the cheap, most commonly used antimalarials continues to
spread alarmingly and could outpace drug development. The artemisinin
derivatives have had an important clinical impact both on the treatment of
resistant falciparum malaria and on the incidence of disease in
low-transmission areas. A few promising new antimalarials are being tested
clinically but there is an imperative need for cheap, well-tolerated drugs that
can be used in short courses, and for strategies to delay the onset of drug
resistance. Bed nets have been shown to reduce the incidence of severe malaria
in many areas but an effective vaccine is urgently needed. |
| doi_str_mv | 10.1146/annurev.med.50.1.179 |
| format | Article |
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tropics. Resistance to the cheap, most commonly used antimalarials continues to
spread alarmingly and could outpace drug development. The artemisinin
derivatives have had an important clinical impact both on the treatment of
resistant falciparum malaria and on the incidence of disease in
low-transmission areas. A few promising new antimalarials are being tested
clinically but there is an imperative need for cheap, well-tolerated drugs that
can be used in short courses, and for strategies to delay the onset of drug
resistance. Bed nets have been shown to reduce the incidence of severe malaria
in many areas but an effective vaccine is urgently needed.</description><identifier>ISSN: 0066-4219</identifier><identifier>EISSN: 1545-326X</identifier><identifier>DOI: 10.1146/annurev.med.50.1.179</identifier><identifier>PMID: 10073271</identifier><identifier>CODEN: ARMCAH</identifier><language>eng</language><publisher>Palo Alto, CA 94303-0139: Annual Reviews</publisher><subject>Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimalarials - administration & dosage ; Antimalarials - economics ; Antimalarials - therapeutic use ; Antiparasitic agents ; Artemisinins ; Bedding and Linens ; Biological and medical sciences ; Drug Costs ; Drug Resistance ; Drugs, Chinese Herbal - therapeutic use ; falciparum ; Histamine ; Humans ; Incidence ; Infections ; Malaria ; Malaria - drug therapy ; Malaria - prevention & control ; Malaria - transmission ; Malaria Vaccines ; Malaria, Falciparum - drug therapy ; Malaria, Falciparum - prevention & control ; Malaria, Falciparum - transmission ; Medical sciences ; Mosquitoes ; Parasites ; Pharmacology. Drug treatments ; Plasmodium ; prophylaxis ; Protective Devices ; Sesquiterpenes - therapeutic use ; therapy ; Tropical Climate</subject><ispartof>Annual review of medicine, 1999-01, Vol.50 (1), p.179-192</ispartof><rights>Copyright © 1999 by Annual Reviews. All rights reserved</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Annual Reviews, Inc. 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a506t-59800727dcd6d283264692b4dcf784af11ea3655a5728f3a4ec3f8afbb957dc3</citedby><cites>FETCH-LOGICAL-a506t-59800727dcd6d283264692b4dcf784af11ea3655a5728f3a4ec3f8afbb957dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.med.50.1.179?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev.med.50.1.179$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4168,27901,27902,77996,77997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1700960$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10073271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newton, BM, DPhil, MRCP, Paul</creatorcontrib><creatorcontrib>White, DSc, MD, FRCP, Nicholas</creatorcontrib><title>MALARIA: New Developments in Treatment and Prevention</title><title>Annual review of medicine</title><addtitle>Annu Rev Med</addtitle><description>Malaria still kills some 0.5-2.5 million people per year in the
tropics. Resistance to the cheap, most commonly used antimalarials continues to
spread alarmingly and could outpace drug development. The artemisinin
derivatives have had an important clinical impact both on the treatment of
resistant falciparum malaria and on the incidence of disease in
low-transmission areas. A few promising new antimalarials are being tested
clinically but there is an imperative need for cheap, well-tolerated drugs that
can be used in short courses, and for strategies to delay the onset of drug
resistance. Bed nets have been shown to reduce the incidence of severe malaria
in many areas but an effective vaccine is urgently needed.</description><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimalarials - administration & dosage</subject><subject>Antimalarials - economics</subject><subject>Antimalarials - therapeutic use</subject><subject>Antiparasitic agents</subject><subject>Artemisinins</subject><subject>Bedding and Linens</subject><subject>Biological and medical sciences</subject><subject>Drug Costs</subject><subject>Drug Resistance</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>falciparum</subject><subject>Histamine</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Malaria</subject><subject>Malaria - drug therapy</subject><subject>Malaria - prevention & control</subject><subject>Malaria - transmission</subject><subject>Malaria Vaccines</subject><subject>Malaria, Falciparum - drug therapy</subject><subject>Malaria, Falciparum - prevention & control</subject><subject>Malaria, Falciparum - transmission</subject><subject>Medical sciences</subject><subject>Mosquitoes</subject><subject>Parasites</subject><subject>Pharmacology. Drug treatments</subject><subject>Plasmodium</subject><subject>prophylaxis</subject><subject>Protective Devices</subject><subject>Sesquiterpenes - therapeutic use</subject><subject>therapy</subject><subject>Tropical Climate</subject><issn>0066-4219</issn><issn>1545-326X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1LAzEQhoMotlb_gcgi4m1rvrPxVupXoX4gPXgL2d0EVnazNem2-O_N0kLBi56SzDwz78wbAM4RHCNE-Y12rvNmPW5MOWYxNkZCHoAhYpSlBPOPQzCEkPOUYiQH4CSETwihJCQ7BgMEoSBYoCFgz5P55H02uU1ezCa5M2tTt8vGuFVIKpcsvNGr_pVoVyZvUS7eq9adgiOr62DOducILB7uF9OndP76OJtO5qlmkK9SJrMohEVZlLzEWZyKcolzWhZWZFRbhIwmnDHNBM4s0dQUxGba5rlksYiMwPW27dK3X50JK9VUoTB1rZ1pu6C45ChjAv4JIkEI45hG8PIX-Nl23sUdFMaYC8REFiG6hQrfhuCNVUtfNdp_KwRV773aea-i94rFWBSQsexi17vL-8S-aGt2BK52gA6Frq3XrqjCnhPxf3i_jNxivYquo05lNuF_M_wAlBChXg</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Newton, BM, DPhil, MRCP, Paul</creator><creator>White, DSc, MD, FRCP, Nicholas</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>RC3</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>MALARIA: New Developments in Treatment and Prevention</title><author>Newton, BM, DPhil, MRCP, Paul ; White, DSc, MD, FRCP, Nicholas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a506t-59800727dcd6d283264692b4dcf784af11ea3655a5728f3a4ec3f8afbb957dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimalarials - administration & dosage</topic><topic>Antimalarials - economics</topic><topic>Antimalarials - therapeutic use</topic><topic>Antiparasitic agents</topic><topic>Artemisinins</topic><topic>Bedding and Linens</topic><topic>Biological and medical sciences</topic><topic>Drug Costs</topic><topic>Drug Resistance</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>falciparum</topic><topic>Histamine</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infections</topic><topic>Malaria</topic><topic>Malaria - drug therapy</topic><topic>Malaria - prevention & control</topic><topic>Malaria - transmission</topic><topic>Malaria Vaccines</topic><topic>Malaria, Falciparum - drug therapy</topic><topic>Malaria, Falciparum - prevention & control</topic><topic>Malaria, Falciparum - transmission</topic><topic>Medical sciences</topic><topic>Mosquitoes</topic><topic>Parasites</topic><topic>Pharmacology. Drug treatments</topic><topic>Plasmodium</topic><topic>prophylaxis</topic><topic>Protective Devices</topic><topic>Sesquiterpenes - therapeutic use</topic><topic>therapy</topic><topic>Tropical Climate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newton, BM, DPhil, MRCP, Paul</creatorcontrib><creatorcontrib>White, DSc, MD, FRCP, Nicholas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Research Library China</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newton, BM, DPhil, MRCP, Paul</au><au>White, DSc, MD, FRCP, Nicholas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MALARIA: New Developments in Treatment and Prevention</atitle><jtitle>Annual review of medicine</jtitle><addtitle>Annu Rev Med</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>50</volume><issue>1</issue><spage>179</spage><epage>192</epage><pages>179-192</pages><issn>0066-4219</issn><eissn>1545-326X</eissn><coden>ARMCAH</coden><abstract>Malaria still kills some 0.5-2.5 million people per year in the
tropics. Resistance to the cheap, most commonly used antimalarials continues to
spread alarmingly and could outpace drug development. The artemisinin
derivatives have had an important clinical impact both on the treatment of
resistant falciparum malaria and on the incidence of disease in
low-transmission areas. A few promising new antimalarials are being tested
clinically but there is an imperative need for cheap, well-tolerated drugs that
can be used in short courses, and for strategies to delay the onset of drug
resistance. Bed nets have been shown to reduce the incidence of severe malaria
in many areas but an effective vaccine is urgently needed.</abstract><cop>Palo Alto, CA 94303-0139</cop><cop>4139 El Camino Way, P.O. Box 10139</cop><cop>USA</cop><pub>Annual Reviews</pub><pmid>10073271</pmid><doi>10.1146/annurev.med.50.1.179</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4219 |
| ispartof | Annual review of medicine, 1999-01, Vol.50 (1), p.179-192 |
| issn | 0066-4219 1545-326X |
| language | eng |
| recordid | cdi_pubmed_primary_10073271 |
| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - administration & dosage Antimalarials - economics Antimalarials - therapeutic use Antiparasitic agents Artemisinins Bedding and Linens Biological and medical sciences Drug Costs Drug Resistance Drugs, Chinese Herbal - therapeutic use falciparum Histamine Humans Incidence Infections Malaria Malaria - drug therapy Malaria - prevention & control Malaria - transmission Malaria Vaccines Malaria, Falciparum - drug therapy Malaria, Falciparum - prevention & control Malaria, Falciparum - transmission Medical sciences Mosquitoes Parasites Pharmacology. Drug treatments Plasmodium prophylaxis Protective Devices Sesquiterpenes - therapeutic use therapy Tropical Climate |
| title | MALARIA: New Developments in Treatment and Prevention |
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