NMR spatial structure of α-conotoxin ImI reveals a common scaffold in snail and snake toxins recognizing neuronal nicotinic acetylcholine receptors

A 600 MHz NMR study of α-conotoxin ImI from Conus imperialis, targeting the α7 neuronal nicotinic acetylcholine receptor (nAChR), is presented. ImI backbone spatial structure is well defined basing on the NOEs, spin-spin coupling constants, and amide protons hydrogen-deuterium exchange data: rmsd of...

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Veröffentlicht in:	FEBS letters 1999-02, Vol.444 (2), p.275-280
Hauptverfasser:	Maslennikov, Innokenty V, Shenkarev, Zakhar O, Zhmak, Maxim N, Ivanov, Vadim T, Methfessel, Christoph, Tsetlin, Victor I, Arseniev, Alexander S
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptor Amino Acid Sequence Cobra Neurotoxin Proteins - chemistry Conotoxin Conotoxins Hydrogen Bonding Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Mollusk Venoms - chemistry Nerve Tissue Proteins - antagonists & inhibitors Neurotoxin Neurotoxins - chemistry Nuclear magnetic resonance structure Oligopeptides - chemistry Protein Binding Protein Structure, Secondary Receptors, Nicotinic - chemistry Snake Venoms - chemistry
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