Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients
Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an inci...
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| Veröffentlicht in: | Arquivos de neuro-psiquiatria 1998-12, Vol.56 (4), p.769 |
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| container_title | Arquivos de neuro-psiquiatria |
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| creator | Mielli, S R Beitler, B Galperin, C Palou, V B Livramento, J A Machado, L dos R Gomes, H R |
| description | Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absence of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma. |
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Protein profile of CSF and serum in 25 patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Mielli, S R ; Beitler, B ; Galperin, C ; Palou, V B ; Livramento, J A ; Machado, L dos R ; Gomes, H R</creator><creatorcontrib>Mielli, S R ; Beitler, B ; Galperin, C ; Palou, V B ; Livramento, J A ; Machado, L dos R ; Gomes, H R</creatorcontrib><description>Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absence of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma.</description><identifier>ISSN: 0004-282X</identifier><identifier>PMID: 10029880</identifier><language>por</language><publisher>Brazil</publisher><subject>Adult ; Cerebrospinal Fluid Proteins - analysis ; Humans ; Immunoglobulin G - blood ; Lymphoma, Non-Hodgkin - blood ; Lymphoma, Non-Hodgkin - cerebrospinal fluid ; Lymphoma, Non-Hodgkin - complications ; Nephelometry and Turbidimetry ; Serum Albumin - analysis</subject><ispartof>Arquivos de neuro-psiquiatria, 1998-12, Vol.56 (4), p.769</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10029880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mielli, S R</creatorcontrib><creatorcontrib>Beitler, B</creatorcontrib><creatorcontrib>Galperin, C</creatorcontrib><creatorcontrib>Palou, V B</creatorcontrib><creatorcontrib>Livramento, J A</creatorcontrib><creatorcontrib>Machado, L dos R</creatorcontrib><creatorcontrib>Gomes, H R</creatorcontrib><title>Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients</title><title>Arquivos de neuro-psiquiatria</title><addtitle>Arq Neuropsiquiatr</addtitle><description>Twenty-five non-Hodgkin's adult patients of a cohort studied for detection of neurologic involvement were evaluated on the cerebrospinal fluid (CSF) protein profile. CSF and serum were collected in the same occasion. Blood-brain barrier and local synthesis of IgG were studied. There was an incidence of neurologic signs and symptoms in 48% of all patients. Samples analysis showed: increase of total protein in CSF in 52%; local synthesis of IgG in one HIV seropositive patient; IgG concentration increase in the CSF in the absence of malignant cells in the CSF in two patients that clinically improved after chemotherapy; oligoclonal bands only in the CSF in one HTLV-I seropositive patient. These data show that the study of CSF protein profile can contribute in the characterization of CNS involvement in non-Hodgkin lymphoma.</description><subject>Adult</subject><subject>Cerebrospinal Fluid Proteins - analysis</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Lymphoma, Non-Hodgkin - blood</subject><subject>Lymphoma, Non-Hodgkin - cerebrospinal fluid</subject><subject>Lymphoma, Non-Hodgkin - complications</subject><subject>Nephelometry and Turbidimetry</subject><subject>Serum Albumin - analysis</subject><issn>0004-282X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjrsKwjAYRjMotl5eQf4XqMRYsZ2LpZMKOriVSBKN5kaSDn17K-js9J0PznBGKMUY5xkpyDVB0xCeGJO8LHcTlKwHLIsCp-h4sCZrLLu_pAHVa_ewmsLAlHUqhhWcvI18-M5bIRUHK6A610ANg8B9pz8u2YKjUXITwxyNBVWBL747Q8t6f6mazHU3zVnrvNTU9-2vYPNXeAP_YDq5</recordid><startdate>199812</startdate><enddate>199812</enddate><creator>Mielli, S R</creator><creator>Beitler, B</creator><creator>Galperin, C</creator><creator>Palou, V B</creator><creator>Livramento, J A</creator><creator>Machado, L dos R</creator><creator>Gomes, H R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199812</creationdate><title>Non-Hodgkin lymphoma in adults. 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| fulltext | fulltext |
| identifier | ISSN: 0004-282X |
| ispartof | Arquivos de neuro-psiquiatria, 1998-12, Vol.56 (4), p.769 |
| issn | 0004-282X |
| language | por |
| recordid | cdi_pubmed_primary_10029880 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Cerebrospinal Fluid Proteins - analysis Humans Immunoglobulin G - blood Lymphoma, Non-Hodgkin - blood Lymphoma, Non-Hodgkin - cerebrospinal fluid Lymphoma, Non-Hodgkin - complications Nephelometry and Turbidimetry Serum Albumin - analysis |
| title | Non-Hodgkin lymphoma in adults. Protein profile of CSF and serum in 25 patients |
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