Granuloma faciale with Extrafacial Lesions
Extrafacial involvement in granuloma faciale (GF) is rather exceptional. We report herein a patient with GF associated with lesions on the trunk and the forearm. Histological studies of facial and extrafacial lesions shared similar characteristics: a mixed inflammatory infiltrate with abundant eosin...
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| Veröffentlicht in: | Dermatology (Basel) 1999-01, Vol.198 (1), p.79-82 |
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| creator | Roustan, G. Sánchez Yus, E. Salas, C. Simón, A. |
| description | Extrafacial involvement in granuloma faciale (GF) is rather exceptional. We report herein a patient with GF associated with lesions on the trunk and the forearm. Histological studies of facial and extrafacial lesions shared similar characteristics: a mixed inflammatory infiltrate with abundant eosinophils in the superficial and middle dermis with a narrow grenz zone of uninvolved dermis between the epidermis and the infiltrate. Evidence of vasculitis was clearly observed in both biopsy specimens. Treatment with dapsone did not alter the course of the disease. We review the 12 cases of extrafacial GF that have been reported in the English and Spanish literature. In these cases a diagnosis of erythema elevatum diutinum (EED) may be suggested. Although GF and EED may share some pathogenic mechanisms, there are several clinical and histological differences between them that make us consider EED and GF as distinct entities. |
| doi_str_mv | 10.1159/000018071 |
| format | Article |
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We report herein a patient with GF associated with lesions on the trunk and the forearm. Histological studies of facial and extrafacial lesions shared similar characteristics: a mixed inflammatory infiltrate with abundant eosinophils in the superficial and middle dermis with a narrow grenz zone of uninvolved dermis between the epidermis and the infiltrate. Evidence of vasculitis was clearly observed in both biopsy specimens. Treatment with dapsone did not alter the course of the disease. We review the 12 cases of extrafacial GF that have been reported in the English and Spanish literature. In these cases a diagnosis of erythema elevatum diutinum (EED) may be suggested. Although GF and EED may share some pathogenic mechanisms, there are several clinical and histological differences between them that make us consider EED and GF as distinct entities.</description><identifier>ISSN: 1018-8665</identifier><identifier>EISSN: 1421-9832</identifier><identifier>DOI: 10.1159/000018071</identifier><identifier>PMID: 10026409</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Biological and medical sciences ; Case Report ; Dermatology ; Facial Dermatoses - pathology ; Female ; Forearm ; Granuloma - pathology ; Humans ; Male ; Medical sciences ; Middle Aged ; Skin - pathology ; Vascular disorders of the skin</subject><ispartof>Dermatology (Basel), 1999-01, Vol.198 (1), p.79-82</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright (c) 1999 S. 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We report herein a patient with GF associated with lesions on the trunk and the forearm. Histological studies of facial and extrafacial lesions shared similar characteristics: a mixed inflammatory infiltrate with abundant eosinophils in the superficial and middle dermis with a narrow grenz zone of uninvolved dermis between the epidermis and the infiltrate. Evidence of vasculitis was clearly observed in both biopsy specimens. Treatment with dapsone did not alter the course of the disease. We review the 12 cases of extrafacial GF that have been reported in the English and Spanish literature. In these cases a diagnosis of erythema elevatum diutinum (EED) may be suggested. Although GF and EED may share some pathogenic mechanisms, there are several clinical and histological differences between them that make us consider EED and GF as distinct entities.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Case Report</subject><subject>Dermatology</subject><subject>Facial Dermatoses - pathology</subject><subject>Female</subject><subject>Forearm</subject><subject>Granuloma - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Skin - pathology</subject><subject>Vascular disorders of the skin</subject><issn>1018-8665</issn><issn>1421-9832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0N1LwzAQAPAgitPpg8-CDBFBoZqkzdejzDmFiSB7L9c00c52nUmL-t8b7dhEBJOHHMmPu8shdEDwBSFMXeKwiMSCbKAdklASKRnTzRCH20hyznpo1_tZUFQKtY16JEQ8wWoHnY8dzNuyrmBgQRdQmsFb0TwPRu-Ng-5mMDG-qOd-D21ZKL3ZX559NL0ZTYe30eRhfDe8mkQ6IayJpA01TKwhUdrGYCkBTWmSWSUJV1TnFseGx0CSnGHLIOOgpGGZzrRmRMZ9dNqlXbj6tTW-SavCa1OWMDd161OumORC_Q8pVmGLOMDjX3BWt24e_pBSwbDAgrKAzjqkXe29MzZduKIC95ESnH5NOV1NOdijZcI2q0z-Q3ZjDeBkCcBrKG2YsS782nEhVCLWjb2AezJu9X79eP9dKF3kNqDDP1HXyieedJYb</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Roustan, G.</creator><creator>Sánchez Yus, E.</creator><creator>Salas, C.</creator><creator>Simón, A.</creator><general>Karger</general><general>S. 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We report herein a patient with GF associated with lesions on the trunk and the forearm. Histological studies of facial and extrafacial lesions shared similar characteristics: a mixed inflammatory infiltrate with abundant eosinophils in the superficial and middle dermis with a narrow grenz zone of uninvolved dermis between the epidermis and the infiltrate. Evidence of vasculitis was clearly observed in both biopsy specimens. Treatment with dapsone did not alter the course of the disease. We review the 12 cases of extrafacial GF that have been reported in the English and Spanish literature. In these cases a diagnosis of erythema elevatum diutinum (EED) may be suggested. Although GF and EED may share some pathogenic mechanisms, there are several clinical and histological differences between them that make us consider EED and GF as distinct entities.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10026409</pmid><doi>10.1159/000018071</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Case Report Dermatology Facial Dermatoses - pathology Female Forearm Granuloma - pathology Humans Male Medical sciences Middle Aged Skin - pathology Vascular disorders of the skin |
| title | Granuloma faciale with Extrafacial Lesions |
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